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Study reveals ‘weak’,’strong’ cells bonding boosts body’s diabetes fight

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Washington [US], January 29 (ANI): Scientists have broadened understanding of how ‘weak’ cells bond with their more mature cellular counterparts to boost the body’s production of insulin, improving our knowledge of the processes leading to type 2 diabetes.
An international research team – led by scientists at the University of Birmingham – have discovered that immature b-cells (PDX1LOW/MAFALOW) are able to overcome their relative deficiencies by partnering with ‘stronger’ counterparts to drive insulin release.
Type 2 diabetes mellitus occurs when b-cells cannot release enough insulin – a tightly controlled process requiring hundreds of such cells clustered together to co-ordinate their response to signals from food, such as sugar, fat and gut hormones.
Publishing their findings today in Nature Communications, the researchers reveal that subtle differences in the levels of PDX1 and MAFA proteins (found only in b-cells), and more broadly, differences in b-cell maturity, contribute to how clusters of insulin-producing cells, known as islets, function.
The corresponding author David Hodson, Professor of Cellular Metabolism, at the University of Birmingham, commented: “Our research shows that differences in b-cell maturity, defined using PDX1 and MAFA levels, are needed across the islet for proper insulin release. Unexpectedly, increases in the proportion of mature b-cells is associated with islet failure. It seems that, rather like society, the islet needs cells with all ages to be properly functional.
“Redressing the balance between immature and mature b-cells restores islet function under conditions of metabolic stress – an excess of sugar and fat in the diet – providing evidence that both ‘weak’ and ‘strong’ b-cells could contribute to proper islet function and insulin release.
“This is the first glimpse that immature cells might contribute to the regulation of insulin release across the islet. Our study indicates a promising line of investigation that could be leveraged to make islets more resilient during type 2 diabetes or when generating new islets in a ‘dish’ for the purpose of transplantation.”
Normally, mature and immature b-cells co-exist within the adult islet and can be grouped into subpopulations according to differences in their levels of specific genes and proteins. Immature b-cells are generally considered to be poorly functional when viewed alone, as single cells.
Researchers found that islets containing proportionally more PDX1HIGH and MAFAHIGH b-cells showed defects in cell function (metabolism, ionic fluxes and insulin secretion). The team believes maintaining a mix of ‘strong’ and ‘weak’ b-cells is important for effective insulin production. (ANI)

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When Kangana Ranaut had an instant smile on her face!

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Mumbai (Maharashtra) [India], February 27 (ANI): Bollywood star Kangana Ranaut who will be seen essaying the role of an Indian Air Force officer in her upcoming flick ‘Tejas’ on Saturday shared a picture showing her character’s name ‘Tejas Gill’ printed on the uniform.
The ‘Queen’ actor hopped on to Instagram and shared that she “had an instant smile on her face” after seeing the name written on the dress.

The photo shows a camouflage-print T-shirt with a tag of ‘Tejas Gill and the blood group B positive.’
Expressing her feelings on seeing the name of her character in the film ‘Tejas’ in front of her, the actor said, “Playing a Sikh soldier in Tejas. I never knew until I read my character’s full name on my uniform today. I had an instant smile on my face. Our longings and love have a way of manifesting. The universe speaks to us in more ways than we understand (added a heart emoticon).”
Meanwhile, Kangana besides ‘Tejas’, will also be seen in ‘Thalaivi’, a biopic on actor-turned-politician Jayalalithaa.
Apart from this she also has ‘Dhaakad’ and ‘Manikarnika Returns: The Legend Of Didda’ in the pipeline.
Kangana has also signed up to play the role of former Prime Minister Indira Gandhi in an upcoming political drama. (ANI)

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Julia Roberts, George Clooney collaborate for Universals’ rom-com ‘Ticket to Paradise’

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Washington [US], February 27 (ANI): Oscar winning American superstars Julia Roberts and George Clooney are set to play lead roles in Universals’ upcoming romantic-comedy titled ‘Ticket to Paradise’.
According to The Hollywood Reporter, Clooney and Roberts will play the role of a divorced couple that will move to Bali to prevent their daughter from repeating a mistake they made 25 years earlier.
The powerhouse pair prior featured together in Jodie Foster’s ‘Money Monster’ and in the Ocean’s ‘Eleven’ film franchise.
Helmed by the ‘Mamma Mia! Here We Go Again’ filmmaker Ol Parker, the upcoming rom-com will be produced by Working Title’s Tim Bevan and Eric Fellner alongside Deborah Balder Stone and Sarah Harvey.
‘Ticket to Paradise’ will be written by Parker and Daniel Pipski. (ANI)

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Study links poor quality carbohydrates rich diet to heart attacks, death risk

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Washington [US], February 27 (ANI): While a balanced diet with an adequate amount of carbohydrates, fats, and sugar is advised to keep diseases at bay, a recent study has pointed out that consuming a diet high in poor quality carbohydrates has many ill effects ranging from a higher risk of heart attacks to strokes, and even death.
The findings of the study were published in the New England Journal of Medicine.
The global study focused on people living in five continents and concluded that a diet high in poor quality carbohydrates leads to a higher risk of heart attacks, strokes, and death.
The higher risks of a diet high in poor quality carbohydrates, called a high glycemic diet, were similar to whether people had previous cardiovascular disease or not.
A total of 137,851 people aged 35 to 70 years old were followed for a median of 9.5 years through the Population Urban and Rural Epidemiology (PURE) study run by the Population Health Research Institute (PHRI) of McMaster University and Hamilton Health Sciences.
The research team used food questionnaires to measure the long-term dietary intake of participants and estimate the glycemic index (the ranking of food based on their effect on blood sugar levels) and glycemic load (the amount of carbohydrates in food times its glycemic index) of diets. There were 8,780 deaths and 8,252 major cardiovascular events recorded among the participants during the follow-up period.
The investigators categorised dietary intake of carbohydrates depending on whether specific types of carbohydrates increased blood sugars more than others (high glycemic index) and compared this index to the occurrence of cardiovascular disease or death.
Those people consuming a diet in the highest 20 per cent of the glycemic index were 50 per cent more likely to have a cardiovascular attack, stroke, or death if they had a pre-existing heart condition, or 20 per cent more likely to have an event if they did not have a pre-existing condition.
These risks were also higher among those people who were obese.
“I have been studying the impact of high glycemic diets for many decades, and this study ratifies that the consumption of high amounts of poor quality carbohydrates is an issue worldwide,” said first author David Jenkins, professor of nutritional sciences and medicine at the University of Toronto’s Temerty Faculty of Medicine, who is also a scientist in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Unity Health Toronto.
“PURE study papers have already indicated that not all carbohydrate foods are the same. Diets high in poor quality carbohydrates are associated with reduced longevity, while diets rich in high-quality carbohydrates such as fruit, vegetables, and legumes have beneficial effects,” he said.
PHRI research investigator Mahshid Dehghan added, “This study also makes it clear that among a diverse population, a diet low in both its glycemic index and load has a lower risk of cardiovascular disease and death.”
Most fruits, vegetables, beans, and intact whole grains have a low glycemic index, while white bread, rice, and potatoes have a high glycemic index.
“The present data, along with prior publications from the PURE and several other studies, emphasize that consumption of poor quality of carbohydrates are likely to be more adverse than the consumption of most fats in the diet,” said Salim Yusuf, senior author of the study.
“This calls for a fundamental shift in our thinking of what types of diet are likely to be harmful and what types neutral or beneficial,” added Yusuf, who is also the principal investigator of the PURE study, executive director of the PHRI, and a professor of medicine at McMaster. (ANI)

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Lady Gaga’s bulldogs are back home

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Washington [US], February 27 (ANI): American pop star Lady Gaga’s beloved French bulldogs have been returned to the star on Saturday (local time) after a robbery incident that took place earlier this week.
According to TMZ, two of the star’s beloved pet dogs named Koji and Gustav were returned to the Los Angeles police by a local woman.
As per reports, the Grammy Award winner’s dog walker was shot in the chest when he was walking with three of the star’s pet dogs. The robbers took two dogs and fled the scene. The third dog was rescued by the officers of the area.
Law enforcement sources told TMZ that “A woman returned the dogs on Friday night to an LAPD station. The dogs were unharmed and have been reunited with Gaga’s team.”
The ‘Rain On Me’ star cried ‘tears of joy’ when she got the news, reported the sources close to the songstress.
Lady Gaga, who was in Rome working on a new movie at the time, offered USD 500,000 for the dogs’ return. Now after the reunion, it is still unclear when the woman will be rewarded the same. (ANI)

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Alia Bhatt pens ‘thank you’ note after ‘Gangubai Kathiawadi’ teaser wins praise

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Mumbai (Maharashtra) [India], February 27 (ANI): Two days after Bollywood star Alia Bhatt’s teaser of her film ‘Gangubai Kathiawadi’ won praise far and wide, the actor penned a note of thanks to her fans and well-wishers.
The ‘Student of the Year’ star hopped on to Twitter and wrote in Hindi, “Aap sab ne Gangu ko itna pyar diya, uske liye THANK YOU!!”

Along with the thank you note, the ‘Highway’ star shared a poster of the film. It shows the actor dressed in a white saree standing near a luxury car and holding a shiny purse in her arm with a ‘beedi’ (leaf cigarette) in her hand.
Bhatt on Wednesday thrilled her fans by dropping the one-minute-thirty-second-long teaser featuring Bhatt portraying an eponymous character in the flick.
The teaser opens with a dialogue that says, “They say…nights in Kamathipura are always moonlit because Gangu lives there!”
The teaser is set in a theme where the 27-year-old named Gangubai Kothewali, a brothel owner and matriarch from Kathiawad who had no choice but to embrace the ways of destiny and swing it in her favour. She is transformed from a brothel queen to a politician.
The teaser showcases Alia in a catchy dialogue: “Live with dignity. Never fear anyone. Neither police, nor MLA, or minister or any bloody pimp…NOBODY!!” and the rising crescendo of a thrumming soundtrack.
The makers have announced the theatrical release date of the film on July 30 this year.
The film marks Bhansali’s first collaboration with Alia. This project will also see Bhansali Productions collaborating with Jayantilal Gada’s Pen India Limited. (ANI)

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Arjun Kapoor, Rakul Preet starrer ‘Sardar Ka Grandson’ to stream on Netflix

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New Delhi [India], February 27 (ANI): Four days after revealing the release date of his much-anticipated comedy-thriller film ‘Bhoot Police’, Bollywood actor Arjun Kapoor has announced his next love drama ‘Sardar Ka Grandson’ for a Netflix release.
The announcement of the movie has come after a year the lead stars of the upcoming romantic-drama, — Arjun Kapoor and Rakul Preet teased fans with an intriguing post on social media.

Months after keeping the information about the project under wraps, both the actors gave a sneak peek of their first collaborative project.

The movie also features veteran actor Neena Gupta in a pivotal role, both the ‘Panipath’ and ‘Yaariyan’ stars shared a series of pictures from the shoot on their Instagram handles.

The pictures were captioned as, “Gather your parents and grandparents for this one, Sardar ka Grandson is coming soon to @netflix_in #SardarKaGrandson.”

It will also star Bollywood actors Aditi Rao Hydari and John Abraham in central roles.
Directed by Kaashvi Nair, ‘Sardar Ka Grandson’ was shot amid the coronavirus pandemic last year, according to sources. The release date of the cross-border love story has still been under wraps.
Meanwhile, on the work front, Arjun, who was last seen in Ashutosh Gowarikar’s period drama ‘Panipat’ also has ‘Sandeep Aur Pinky Faraar’, co-starring Parineeti Chopra, and
‘Bhoot Police’, co-starring Saif Ali Khan, Fatima Sana Shaikh, and Ali Fazal in the pipeline.
Rakul Preet will appear with Ajay Devgn in his directorial ‘Mayday’. Megastar Amitabh Bachchan will portray a pivotal role in the film. Rakul also has action-thriller John Abraham starrer film ‘Attack’ and Bhushan Kumar’s ‘Thank God’ in the pipeline. (ANI)

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