STROKE MIGHT BE INITIAL SIGN OF CARDIOVASCULAR DISEASE AMONG SMOKERS - The Daily Guardian
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STROKE MIGHT BE INITIAL SIGN OF CARDIOVASCULAR DISEASE AMONG SMOKERS

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Death from a heart attack or stroke may be the first cardiovascular disease (CVD) event in some people who smoke cigarettes and CVD is the leading adverse health effect among smokers, according to new research.

The findings of the study were published in the Journal of the American Heart Association, an open-access journal of the American Heart Association.

Decades of research links cigarette smoking to premature death caused by cardiovascular disease and other diseases such as lung cancer. According to the American Heart Association’s Heart and Stroke Statistical Update 2021, more than 480,000 US adults die each year from cigarette smoking.

Despite increasing awareness about the health benefits of quitting smoking, more than 34 million adults in the United States still smoke cigarettes. “There is often more awareness and concern about cancer as a result of smoking than heart disease, so we wanted to better define the risks of smoking-related to different types of cardiovascular disease and, most importantly, to cardiovascular death,” said lead study author Sadiya S. Kahn, MD, M Sc, an assistant professor of medicine in the division of cardiology at Northwestern University’s Feinberg School of Medicine in Chicago.

Khan added, “In our analysis, even after adjusting for deaths not related to the heart, such as those due to lung cancer, we found that fatal or non-fatal events related to cardiovascular disease are more likely to occur among people who smoke.”

The researchers pooled data from nine long-term cohort studies in the US to evaluate multiple lifestyle factors as well as cardiovascular and other health outcomes. The analysis included data from 106,165 adults (50.4 per cent women; 16.2 per cent Black adults; 50.1 per cent cigarette smokers) between the ages of 20 and 79, who were free of cardiovascular disease at the start of the studies.

The new analysis categorized participants by smoking status (either yes or no, self-reported at study enrollment); age (young: 20 to 39 years of age; middle-aged: 40 to 59; and older: 60 to 79); and sex.

Using the combined data, researchers estimated the number of years lived with and without cardiovascular disease according to smoking status and then examined the association between smoking and cardiovascular events after accounting for death from other diseases such as lung cancer. Adjustments were made for age, race, body mass index (BMI), blood pressure and cholesterol levels.

The follow-up time for study participants ranged from 10 to 25 years. The biggest differences in risks and in deaths between the participants who smoked and those who didn’t smoke occurred during middle age. The analysis found: Middle-aged women who smoked were nearly twice as likely as non-smoking women to have a fatal CVD event as their first sign of CVD.Middle-aged men who smoked had a 79 per cent chance of having a fatal CVD event as their first sign of cardiovascular disease – about 1.5 times more likely compared to middle-aged men who did not smoke. For middle-aged women, the long-term rates of CVD risk were nearly 10 per cent higher in those who smoked compared to those who didn’t (34.7 per cent for smokers; 24.8 per cent for non-smokers).

“Our findings note that preventing a heart attack, stroke or heart failure is vital, yet preventing unexpected sudden death as the first manifestation of cardiovascular disease is clearly a priority. People who smoke may not realize the harm cigarettes are causing their bodies until it’s too late,” Khan said.

“Another notable finding among people who smoked was the early onset of CVD, and among those who developed CVD, how much younger they were. There’s not a lot of research on young adults who smoke, particularly among young men. Our study adds important perspective,” Khan added.

Among young adults, 20 to 39 years of age, the analysis found:

The risk for CVD started to increase significantly in young men who smoked near the 10-year follow-up mark, while in young women the increased risk for CVD in those who smoked became more evident near the 20-year follow-up mark.

With respect to CVD subtypes, young men who smoked had the highest long-term risk for heart attacks (24 per cent), while young women had the highest long-term risk (11.3 per cent) for other CVD causes of death, such as stroke or heart failure.

Among all age groups, a majority of the first CVD events were fatal or nonfatal heart attacks. Fatal and nonfatal strokes were the next leading causes of the first CVD event among those in the young age group. Heart failure was the second leading cause among the middle-aged and older age groups.

Khan said these results emphasize the contribution of smoking to the earlier onset of CVD overall, and also affected excess CVD risk well into the eighth decade of life in both men and women, even after adjusting for the competing risk of non-CVD death.

Based on these results, the researchers suggest that all people who smoke should talk with their physicians or other health care professionals about taking steps toward quitting and improving their cardiovascular health.

“These results offer a very compelling message that people who smoke need to hear – smoking can kill you before you even know you have cardiovascular disease. It can, indeed, be a silent killer,” said Esa M. Davis, M.D., a member of the American Heart Association’s Council on Lifestyle and Cardiometabolic Health, associate professor of medicine and the clinical and translational science medical director of the tobacco treatment service of the University of Pittsburgh Medical Center, who was not involved in the study.

Esa added, “Heart attacks, strokes and other types of cardiovascular disease don’t always have early symptoms, so if you don’t know you have CVD, it can’t be treated. You can help prevent CVD by never smoking or stopping smoking as soon as possible.”

The American Heart Association supports ending the use of all combustible tobacco products while ensuring other tobacco products such as electronic cigarettes do not addict the next generation of youth and adolescents. In 2019, the Association announced USD 20 million in research funding to drive scientific discovery that will help end teen tobacco use and addiction.

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Study finds cardiovascular disease, high cholesterol linked to plastics

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A new study has found that phthalate—a chemical used to make plastics more durable—has led to increased plasma cholesterol levels.

The findings of the study were published in the journal ‘Environmental Health Perspectives’. “We found dicyclohexyl phthalate, or DCHP, strongly binds to a receptor called pregnane X receptor, or PXR,” said Changcheng Zhou, who is a professor in the UCR School of Medicine.

“DCHP ‘turns on’ PXR in the gut, inducing the expression of key proteins required for cholesterol absorption and transport. Our experiments show that DCHP elicits high cholesterol by targeting intestinal PXR signalling,” added Zhou.

DCHP, a widely used phthalate plasticiser, has recently been proposed by the Environmental Protection Agency as a high-priority substance for risk evaluation. Not much is known yet about DCHP’s adverse effects on humans.

“To our knowledge, our study is the first to show the effects of DCHP exposure on high cholesterol and cardiovascular disease risk in mouse models. Our results provide insights and new understandings of the impact of plastic-associated chemicals on high cholesterol—or dyslipidemia—and cardiovascular disease risk,” Zhou said.

Zhou’s team also found that mice exposed to DCHP had in their intestines higher circulating “ceramides”—a class of waxy lipid molecules associated with increased cardiovascular disease risk in humans—in a way that was PXR-dependent.

“This, too, points to the potentially important role of PXR in contributing to the harmful effects of plastic-associated chemicals on cardiovascular health in humans,” Zhou said.

Zhou was joined in the research by Zhaojie Meng, Jinwei Liu, Rebecca Hernandez, and Miko Gonzales of UCR; and Yipeng Sui, Taesik Gwag, and Andrew J. Morris of the University of Kentucky.

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DEMENTIA CREATES LISTENING ISSUES IN QUIET, NOISY ENVIRONMENTS

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Listening to the spoken word in noisy environments is challenging for everyone. Acoustic studies show people with mild dementia struggle to understand speech in both noisy and quiet environments, highlighting the need for everyone to communicate clearly.

During the 181st Meeting of the Acoustical Society of America, Kate McClannahan, from Washington University School of Medicine, discussed how background noise impacts have spoken word recognition in people with mild dementia. The talk, “The effect of mild dementia on speech perception in quiet and noise,” took place on Wednesday, December 1, at the Hyatt Regency Seattle.

Difficulty in understanding speech, especially in background noise, is a common concern for older adults. Using a word identification task in quiet and noisy conditions, researchers examined the impact of mild dementia on speech perception. They tested individuals with and without mild dementia.

The scientists found word identification scores of those without dementia were significantly better in all conditions, meaning people with mild dementia symptoms recalled fewer words in both quiet and noisy situations.

In the quiet condition, the group with mild dementia missed around 20 per cent of the words, while the control group missed approximately 5 per cent. The findings indicate individuals with mild dementia struggle with understanding speech, even without background noise.

“What is important to take away from this study is that people who are experiencing mild dementia symptoms may have difficulty understanding speech in both quiet and acoustically challenging situations,” said McClannahan.

McClannahan added, “Therefore, when conversing with someone who may be experiencing cognitive difficulties, considerations such as speaking more clearly and slowly, reducing background noise and distractions, making sure the listener can see the speaker’s face and providing ample contextual information, may help to improve the listener’s speech understanding.”

“If you or a loved one notice difficulty with your communication, seeking the advice and care of an audiologist is a great place to start!” McClannahan said taking these measures will aid effective communication for all listeners.

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Study provides model for treating HIV/AIDS, depression

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For people with HIV who are also struggling with depression, remaining healthy is often an insurmountable challenge, especially in South Africa, home to the highest number of cases in the world and a significant shortage of mental health professionals.

However, a new study has provided local and global implications for successfully treating both mental health and HIV/AIDS in settings like South Africa—or even Miami, the epicentre of new cases in the United States. The findings of the study were published in the ‘Journal of the International AIDS Society’.

In the study, an international team of researchers—led by the University of Miami’s Steven Safren and two colleagues—demonstrated the effectiveness of training nurses in public HIV clinics to deliver a specially adapted cognitive behaviour therapy (CBT) to help people with depression and uncontrolled HIV adhere to their prescribed medication regiment. CBT is a proven approach for changing faulty or unhelpful thinking or behavioural patterns.

“We know that treating HIV-positive people who are clinically depressed with antidepressants alone does not affect their viral loads. Their depression may improve, but their adherence does not,” said Safren, professor of psychology and director of the University’s Center for HIV/AIDS Research and Mental Health.

“So, given the global shortage of mental health professionals, we showed it is possible to train nurses to deliver cognitive-behavioural therapy for adherence and depression (CBT-AD), an intervention that successfully addresses both clinical depression and uncontrolled HIV,” added Safren.

Safren, who joined the University in 2015 from Harvard Medical School, conducted the study in a poor township just outside of Cape Town, South Africa, with fellow researchers John A Joska, director of the HIV Mental Health Research Unit and professor of psychiatry at the University of Cape Town, and Conall O’Cleirigh, associate professor of psychology at Harvard and director of Behavioral Medicine at Massachusetts General Hospital.

For their study, the researchers recruited 161 patients with uncontrolled HIV/AIDS and clinical depression from four public health clinics in the township of Khayelitsha. Although a medical officer could prescribe antidepressants to the patients, the clinics have limited psychological services—as does the country in general. According to the study, South Africa only has 0.28 psychiatrists and 0.32 psychologists per 100,000 people.

At the onset of the study, all participants received the usual enhanced care for clinically depressed HIV-AIDS patients who did not achieve viral suppression after receiving the first month of their antiretroviral medication. That customary treatment included another prescription and follow-up meetings with an adherence counsellor.

But half the patients were also randomly assigned to attend eight CBT-AD sessions, where specially trained nurses integrated strategies for treating depression with adherence counselling that included modules on life skills, depression, relaxation, mood monitoring, and problem-solving.

The idea, Safren said, was to help patients “turn down the volume” of their mental health symptoms, so they would be more open to counselling on the benefit of taking their medication. To track their adherence, the patients also received an electronic pillbox that, every time it was opened, transmitted a real-time signal to a web server.

And, researchers found, the task-shared approach delivered by nurses proved effective. Patients who completed the CBT-AD sessions were more than 2.5 times more likely to achieve undetectable viral loads than those who underwent the usual care.

Now, Safren noted, the next step will be for the research team to evaluate how to sustainably implement the CBT-AD approach in South Africa or even South Florida. He said the task-shared approach could be viable in Miami, where there are fewer services to help people achieve viral suppression than in other US cities with large populations of people living with the virus.

“South Africa has the most cases of HIV/AIDS in the world and Miami is the city with the highest incidence of new cases in the US—so there is a parallel,” Safren pointed out.

“And unlike places like New York or Massachusetts, where people are more likely to be virally suppressed, Florida doesn’t have the same public health resources. If, for example, you’re an HIV patient at Massachusetts General or Fenway Health, where I used to work, and you miss your visit, or your viral load becomes uncontrolled, social workers will swoop in and provide assistance. That doesn’t happen as often in Florida and other places in the US with less public health HIV/AIDS funding,” Safren added.

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ALL YOU NEED TO KNOW ABOUT ZYCOV-D VACCINE

DR SANDEEP PATIL

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Zydus Cadila’s ZyCoV-D, the country’s second indigenous jab against coronavirus (Covid-19), is soon going to be supplied to seven states in India, indicating that our vaccination program will gain more strengthen. This needle-less jab, which received authorisation from the Drugs Controller General of India (DCGI) on 20 August, will be initially administered only to adults because of the company’s limited production capacity currently. However, once the production capacity is strengthened, the vaccine will be available to adolescents too.

HERE IS WHAT YOU SHOULD KNOW ABOUT THE VACCINE

ZyCoV-D is the first Covid-19 vaccine that can be administered using a needle-free applicator as opposed to traditional syringes. It is a three-dose vaccine, whose second and third doses are to be taken 28 and 56 days after the first. The approval has come after evaluating the interim phase III clinical trials in over 28,000 volunteers, in consultation with the Subject Expert Committee. It is also the first Covid-19 vaccine candidate developed on a plasmid DNA platform to be commercially introduced anywhere in the world. The single dose of the vaccine will be made available to the Centre at Rs 376 including the cost of the jet applicator and GST, taking the price of a three-dose jab to Rs 1,128.

WHAT IS A DNA-PLASMID VACCINE?

Most active vaccines are made from a killed or weakened form of the infectious agent. A DNA-plasmid vaccine is a new approach where a piece of DNA containing the genes for the antigens is injected. The body learns to develop an immune response against the antigen, and when the pathogen attacks, the body can then generate the specific antibodies against Covid-19.

HOW DOES THE ZYCOV-D WORK?

The vaccine is jointly developed in partnership with the Department of Biotechnology, had demonstrated a primary efficacy of 66.66% in phase 3 clinical trials. It was the first Covid-19 vaccine in India to be tested in the adolescent population—those in the 12-18-yr age group. It is based on DNA-plasmid technology; it can be administered using a needle-free injection system; and finally, it remains stable in room temperatures for three months. Unlike mRNA vaccines, DNA-based vaccines do not require ultra-cold storage systems and are said to be more cost-effective. The manufacturer also claims that its technology is ideal for tackling Covid-19 as it can be easily adapted to deal with mutations in the virus.

WHAT’S ITS EFFECTIVENESS?

According to the data collected during this trial, this vaccine had already exhibited robust immunogenicity, tolerability and safety profile in the adaptive Phase I/II clinical trials carried out earlier. It said this vaccine works against the Delta variant as the trials have been carried out in more than 50 clinical sites spread across the country, and during the peak of the second wave of Covid-19, have shown the vaccine’s efficacy against the new mutant strains, especially the Delta variant. Data also shows equivalent immunogenicity with that of the three-dose regimen. Therefore, a two-dose regimen approval is also expected. However, the expert panel will review more data on the same.

Going forward, with more vaccines available to the population we can help ebb the pandemic and bring back normalcy to life. Until then, maintaining Covid-19 appropriate behaviour would remain paramount.

The writer is Chief Intensivist, Fortis Hospital, Kalyan.

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STUDY FINDS WHOLE FAT DAIRY AS GOOD AS LOW FAT FOR KIDS

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A team of researchers from Edith Cowan University has found that when it comes to your kids, whole fat milk is as good as low-fat milk.

The study has been published in the ‘American Journal of Clinical Nutrition’. It suggested the current public health advice recommending children over the age of two consume low-fat dairy products may need to be revised.

ECU’s Associate Professor Therese O’Sullivan led the investigation into the consumption of full-fat dairy products in children as part of the Milky Way study.

Over a three-month period, 49 healthy children aged four to six were randomly allocated to receive either whole-fat or low-fat dairy products in place of their normal dairy intake.

Dairy products were home delivered every fortnight in plain packaging at no cost to the participants, to ensure purchase price wasn’t a factor.

Neither group knew whether they were consuming whole-fat or low-fat dairy, while any leftover products were weighed each fortnight to assess the children’s overall intake.

For the first time, researchers comprehensively measured the children’s obesity, body composition, blood pressure, and blood biomarkers to monitor the effects of their dairy consumption. Regardless of whether they were consuming whole-fat or low-fat dairy, both groups of children took in similar amounts of calories.

Although children consuming low-fat dairy took in fewer calories and fat from dairy, they naturally turned to other foods and drinks to make up for this difference.

Professor O’Sullivan said the findings showed no significant differences between the groups’ obesity or cardiovascular health.

“It had previously been thought young children would benefit from low-fat dairy products due to their lower levels of saturated fats and lower density of energy, in turn helping avoid obesity and risk of associated cardiometabolic diseases,” she said.

“Our results suggest healthy children can safely consume whole-fat dairy products without increased obesity or adverse cardiometabolic effects. With consideration of our results and previous research, future revisions of dietary guidelines should consider recommending children aged two and over can consume either whole fat or reduced-fat dairy,” she added.

Dietitian and PhD candidate on the study Analise Nicholl said that this would make life easier for parents.

“This evidence-based approach would help simplify parents’ dairy choices and allow children to consume dairy according to their individual preference,” Analise said.

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Medical training takes less mental toll than a decade ago: Study

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It took more than a decade for researchers to track the mental health of medical interns in their most stressful time of training. However, it has been found that things have gotten better now.

This research was published in the ‘Annals of Internal Medicine Journal’. But those first-year residents, or interns, still have a sizable risk of developing depression. And many who do still don’t seek help.

The jump in depression scored over the course of the first post-medical school year has gotten 25% smaller from 2007 to 2019, according to the study of nearly 17,000 new doctors led by a team from the University of Michigan Medical School.

To help understand potential drivers of the effect, the team explored individual and residency program factors previously shown to be linked to depression among training doctors. The study suggested, but can’t prove, that reduced work hours, slightly increased sleep, more feedback from supervisors and increased use of mental health care contributed to the change in depressive symptoms over time. Data from the participants showed significant changes in all of these measures.

The findings came from the Intern Health Study, which has used wearable activity trackers, mobile apps, surveys and genetic tests to study medical interns at hundreds of teaching hospitals.

In addition to tracking a group with a known high risk of depression, the study provided a way to study the effects of intense, prolonged stress more generally.

That’s why the new results could have impacted beyond medical training. Other stressful jobs and long-term stressful situations might also benefit from the increased attention to reducing depression-related stressors that the graduate medical education community has focused on in recent years.

“The Intern Health Study offers a unique dataset for us to study the trend of this population’s mental health over a long time span,” said Yu Fang, M.S.E., the study’s first author and a researcher at the Michigan Neuroscience Institute.

“The story we have learned from these data could help to make strategic plans in shaping a better medical internship experience in the future,” Fang added.

Srijan Sen, M.D., PhD, the leader of the Intern Health Study, said, “Given that depression rates are still very high, compared to the general population, we are hopeful that the drivers of improvement over the past 13 years can help guide areas to focus on to catalyse even more improvement going forward.”

Sen is director of the U-M Frances and Kenneth Eisenberg and Family Depression Center, and a professor in MNI and the Department of Psychiatry at Michigan Medicine.

The reduction in the size of the depression-score jump came despite the fact that interns in later years were more likely to have risk factors for depression, including a history of the condition.

The data showed that interns’ work hours dropped by 11 per cent over the 13-year period, sleep hours per day went up nearly 5 per cent, and the percentage of residents with current depression who were getting professional help went from 14 per cent to 38 per cent.

Over the course of the 13 years studied, female interns experienced a more pronounced reduction in the magnitude of depression symptom increases across the intern year, and they were much more likely to seek mental health care. The percentage of interns who were female also increased over the 13-year study period.

The same was true for interns in non-surgical fields compared with those pursuing training in surgery or another surgery-based speciality; the reduction in work hours was larger in non-surgical interns.

The study did not show any measurable difference between those whose intern year included the first months of the Covid-19 pandemic and those who trained before. Other research from the Intern Health Study is looking at the impacts of the pandemic, including one already-published study about interns taking part in the study in China.

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