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Night shift work may increase cancer risk, says study

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Washington [US], March 8 (ANI): A new study conducted by researchers at Washington State University has found new clues as to why night shift workers may be at increased risk of developing certain types of cancer compared to those who work regular daytime hours.
Findings suggest that night shifts disrupt natural 24-hour rhythms in the activity of certain cancer-related genes, making night shift workers more vulnerable to DNA damage while also causing the body’s DNA repair mechanisms to be mistimed to deal with that damage.
Published online in the Journal of Pineal Research, the study involved a controlled laboratory experiment that used healthy volunteers who were on simulated night shift or day shift schedules.
Though more research still needs to be done, these discoveries could someday be used to help prevent and treat cancer in night shift workers.
“There has been mounting evidence that cancer is more prevalent in night shift workers, which led the World Health Organization’s International Agency for Research on Cancer to classify night shift work as a probable carcinogenic,” said co-corresponding author Shobhan Gaddameedhi, an associate professor formerly with the WSU College of Pharmacy and Pharmaceutical Sciences and now with North Carolina State University’s Biological Sciences Department and Center for Human Health and the Environment.
“However, it has been unclear why night shift work elevates cancer risk, which our study sought to address.”
As part of a partnership between the WSU Sleep and Performance Research Center and the U.S. Department of Energy’s Pacific Northwest National Laboratory (PNNL), Gaddameedhi and other WSU scientists worked with bioinformatics experts at PNNL to study the potential involvement of the biological clock, the body’s built-in mechanism that keeps us on a 24-hour night and day cycle.
Though there is a central biological clock in the brain, nearly every cell in the body also has its own built-in clock. This cellular clock involves genes known as clock genes that are rhythmic in their expression, meaning their activity levels vary with the time of day or night. The researchers hypothesized that the expression of genes associated with cancer might be rhythmic, too, and that night shift work might disrupt the rhythmicity of these genes.
To test this, they conducted a simulated shift work experiment that had 14 participants spend seven days inside the sleep laboratory at WSU Health Sciences Spokane. Half of them completed a three-day simulated night shift schedule, while the other half were on a three-day simulated day shift schedule.
After completing their simulated shifts, all participants were kept in a constant routine protocol that is used to study humans’ internally generated biological rhythms independent of any external influences.
As part of the protocol, they were kept awake for 24 hours in a semi-reclined posture under constant light exposure and room temperature and were given identical snacks every hour. Every three hours a blood sample was drawn.
Analyses of white blood cells taken from the blood samples showed that the rhythms of many of the cancer-related genes were different in the night shift condition compared to the day shift condition. Notably, genes related to DNA repair that showed distinct rhythms in the day shift condition lost their rhythmicity in the night shift condition.
The researchers then looked at what the consequences of the changes in the expression of cancer-related genes might be. They found that white blood cells isolated from the blood of night shift participants showed more evidence of DNA damage than those of day shift participants.
What’s more, after the researchers exposed isolated white blood cells to ionizing radiation at two different times of day, cells that were radiated in the evening showed increased DNA damage in the night shift condition as compared to the day shift condition.
This meant that white blood cells from night shift participants were more vulnerable to external damage from radiation, a known risk factor for DNA damage and cancer.
“Taken together, these findings suggest that night shift schedules throw off the timing of expression of cancer-related genes in a way that reduces the effectiveness of the body’s DNA repair processes when they are most needed,” said co-corresponding author Jason McDermott, a computational scientist with the Pacific Northwest National Laboratory’s Biological Sciences Division.
The researchers’ next step is to conduct the same experiment with real-world shift workers who have been consistently on day or night shifts for many years to determine whether in night workers the unrepaired DNA damage builds up over time, which could ultimately increase the risk of cancer.
If what happens in real-world shift workers is consistent with the current findings, this work could eventually be used to develop prevention strategies and drugs that could address the mistiming of DNA repair processes.
It could also be the basis for strategies to optimize the timing of cancer therapy so that treatment is administered when effectiveness is greatest and side effects are minimal, a procedure called chronotherapy that would need to be fine-tuned to the internal rhythms of night workers.
“Nightshift workers face considerable health disparities, ranging from increased risks of metabolic and cardiovascular disease to mental health disorders and cancer,” said co-senior author Hans Van Dongen, a professor in the WSU Elson S. Floyd College of Medicine and director of the WSU Sleep and Performance Research Center.
“It is high time that we find diagnosis and treatment solutions for this underserved group of essential workers so that the medical community can address their unique health challenges.” (ANI)

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I ABSOLUTELY LOVED THE PROCESS: RADHIKA APTE ON HER DIRECTORIAL DEBUT

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Mumbai: Actress Radhika Apte has donned many hats while portraying different roles for her films and now she has taken up direction too. The actress released her directorial debut ‘The Sleepwalkers’ trailer in the lockdown at Palms Spring International Short Fest which won ‘The Best Midnight Short’ award.

Making her directorial debut with the short-film titled The Sleepwalkers, the actress in a recent interview with a leading publication shared, “I had never thought of making films. There was no such plan. I just had the urge to write because sometimes you want to create content that challenges you. Roles that come your way are not necessarily from the space that you want them to come from. I just wanted to write something that interested me. There are things that I passionately want to do. When I bounced off the story to Honey Trehan and Abhishek Chaubey, they decided to make it. I had 10 days for the prep and shoot. When I finished writing, I realised I didn’t want to act in it, but I wanted to direct it. And, I absolutely loved the process.”

Fans of the actress cannot wait to witness the magic Radhika has created, this time being behind the lens. The trailer of her short-film has been showered with lot of appreciation from the audiences.

 Her performance in the recently released OK Computer was widely appreciated and she will be next seen in ‘Mrs Undercover’ playing the role of a housewife who turns Undercover agent.

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IT IS MY RESPONSIBILITY TO INSPIRE YOUNG WOMEN: SANYA MALHOTRA

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New Delhi : Bollywood actress Sanya Malhotra is garnering tremendous praise and appreciation from the audience for her recent release, ‘Pagglait’. The film shows the actress as a strong headed woman, who does not budge to societal expectations and norms and it has become a source of inspiration for many young women. 

Her diverse filmography boasts of strong woman-centric roles and characters, which is in turn a blessing for many. In a recent interview with a leading publication, Sanya revealed, “I am attracted to these characters. As an audience, I love watching such women on screen.”

She further adds, “As an actor, I think somewhere it is my responsibility to inspire young women who are watching films.”

Over the past few years, Sanya has been playing pivotal roles, from where young women can draw inspiration. And being a director’s actor, Sanya has been able to meet the expectations of the audience with her impeccable performance in movies like, ‘Badhaai Ho’, ‘Pataakha’, ‘Dangal’ and ‘Shakuntala Devi’.  Other than this, Sanya has a vast trajectory of upcoming films like ‘Meenakshi Sundereshwar’ and ‘Love Hostel’.

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LADY GAGA THANKS FANS AFTER 2013 ALBUM ‘ARTPOP’ RETURNED ON ITUNES TOP 10 CHART

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Los Angeles: American singer-actor Lady Gaga recently shared an emotional message with fans after her 2013 album ‘Artpop’ returned to the Top 10 chart on iTunes.According to Fox News, in a Change.org petition, over 40,000 fans signed an online document demanding that Interscope Records release the B-side of the ‘Artpop’ album, also called ‘Act II’ after DJ White Shadow, a producer on the album, teased she has a number of unreleased songs. Fans said they wanted to “show the Haus of Gaga that we still care about the experimental album and that chart success does not matter.”The Grammy-winning singer reacted to her album’s newfound popularity with a sweet message on Twitter.“The petition to #buyARTPOPoniTunes for a volume II has inspired such a tremendous warmth in my heart. Making this album was like heart surgery, I was desperate, in pain, and poured my heart into electronic music that slammed harder than any drug I could find,” she wrote.“I fell apart after I released this album. Thank you for celebrating something that once felt like destruction. We always believed it was ahead of its time. Years later turns out, sometimes, artists know. And so do little monsters. Paws up,” wrote Gaga.Per Fox News, when the album originally dropped, it received mixed reviews like The New York Times saying it pumped “so insistently it sometimes forgets to breathe.”Gaga also included R. Kelly in the song ‘Do What U Want’ but has since removed him and apologised for working with an alleged sexual abuser.“I’m sorry, both for my poor judgment when I was young, and for not speaking out sooner,” she said in 2019 via Twitter. 

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‘ARMY OF THE DEAD’: HUMA QURESHI’S DEBUT HOLLYWOOD FILM TRAILER OUT

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Washington: The trailer of Zack Snyder’s zombie heist film – ‘Army of the Dead’ dropped on Tuesday, and it is surely one of the most awaited films of the year.Movie buffs can finally catch a glimpse of Bollywood actor Huma Qureshi’s debut Hollywood venture. While the details of Huma’s character is still under wraps, makers have just revealed that her character is named Geeta in the film. With Dave Bautista leading the cast, the film will follow a group of men and women who come together to stage a heist at a casino in Vegas.From filmmaker Zack Snyder (300, Watchmen, Zack Snyder’s Justice League), ‘Army of the Dead’ takes place following a zombie outbreak that has left Las Vegas in ruins and walled off from the rest of the world.When Scott Ward (Dave Bautista), a former zombie war hero who is now flipping burgers on the outskirts of the town he now calls home, is approached by casino boss Bly Tanaka (Hiroyuki Sanada), it is with the ultimate proposition: break into the zombie-infested quarantined zone to retrieve USD 200 million sitting in a vault beneath the strip before the city is nuked by the government in 32 hours.With little left to lose, Ward takes on the challenge, assembling a ragtag team of experts for the heist. With a ticking clock, a notoriously impenetrable vault, and a smarter, faster horde of Alpha zombies closing in, only one thing’s for certain in the greatest heist ever attempted: survivors take all.The movie that is slated to release on May 21 on Netflix stars Dave Bautista, Ella Purnell, Omari Hardwick, Ana de la Reguera, Theo Rossi, Matthias Schweighofer, Nora Arnezeder, Hiroyuki Sanada, Tig Notaro, Raul Castillo, Huma Qureshi, Samantha Win, Michael Cassidy, Richard Cetrone, and Garret Dillahunt.

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RANVEER COLLABORATES WITH SHANKAR FOR OFFICIAL REMAKE OF TAMIL HIT ‘ANNIYAN’

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Movie buffs have a reason to rejoice! Two forces of Indian cinema – iconic director Shankar and Bollywood superstar Ranveer Singh are coming together for the remake of the filmmaker’s 2005 cult blockbuster ‘Anniyan’.This is anticipated to be one of the biggest director-actor collaborations in recent times. Shankar, known for his path-breaking, larger-than-life vision, and Ranveer, who has given India some of the most unforgettable and lovable characters on-screen, are coming together in an unprecedented creative coup. Shankar will be directing Ranveer in the official adaptation of ‘Anniyan’, which will be mounted on a gigantic cinematic canvas, proving it to be one of the biggest pan-India projects.The yet-untitled project is being interestingly announced around the auspicious time of Baisakhi in North India and Puthandu in Tamil Nadu, which marks the New Year celebrations in these respective calendars.Expressing his excitement, Shankar said, “For it to be made into a Hindi film, Anniyan needed a maverick, charismatic showman like no other to play the part. I found this in the mercurial Ranveer Singh because he is a once-in-a-generation actor who has shown us that he can immortalise a character through his stellar performance.”“I’m thrilled to make Anniyan for the pan-Indian audience and I’m confident that this powerful story will strike a chord in the hearts of all. In Dr. Gada, Ranveer and I have found an ideal producer who believes in the vision we have to change the nativity of content for audiences across the country,” he added.Blessed to have this opportunity, Ranveer acknowledged Shankar for being a true disruptor who always brings exceptional ideas to the screen. He also disclosed that he had always hoped and dreamed of collaborating with the 57-year-old ace filmmaker.“To lead a film like Anniyan is a dream come true for any artiste. Vikram Sir, one of our country’s finest talents, an artiste who I hugely admire, gave a colossal performance in the original, one that can never be matched,” Ranveer said of the upcoming project.“I can only hope that my interpretation and rendition of the part also connects with audiences in the same way. It’s undoubtedly a once-in-a-lifetime performance piece, and I am ready to give this role every single ounce of my being. Shankar Sir is a genius filmmaker and a true visionary. Words don’t do justice to just how excited I am at the prospect of being directed by him,” he added.Bringing these creative giants together for the very first time will be veteran film producer Dr Jayantilal Gada, Chairman and M.D. of Pen Studios.Speaking about the creative coup, he said, “It is an opportunity of a lifetime for us and we are thrilled to partner with the two powerhouses as producers and worldwide distributors of the film. We are confident that their collaboration will write a new chapter in the history of Indian cinema.”

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ALIA BHATT TESTS NEGATIVE FOR COVID-19, SHARES A BEAUTIFUL SUN-KISSED PICTURE

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Bollywood star Alia Bhatt on Wednesday announced that she has finally tested negative for COVID-19, after almost 15 days of home quarantine.The ‘Student of The Year’ actor took to her Instagram handle and shared an all-smiles sun-kissed picture to inform her fans about the good news. In the picture, Alia can be seen sporting a blue sweatshirt, and pink pyjamas as she poses in the garden while looking into the lens. The actor looks gorgeous in a no-makeup look with her luscious locks open.

Alia captioned the post, “the only time being negative is a good thing” and added flex muscle and dancing girl emoticons.Celebrity followers including fashion designer Ami Patel and more than 1 lakh fans liked the post, while many congratulated the actor on winning the battle against the novel coronavirus.The second wave of coronavirus has infected a lot of people and the number of COVID-19 positive cases has been rapidly rising. In Bollywood, an array of celebrities like Ranbir Kapoor, Akshay Kumar, Aditya Narayan, Kartik Aaryan, and Aamir Khan among others have got infected within a span of a few weeks.On the work front, Alia, who was last seen in the 2020 film ‘Sadak 2’, will be next seen in Ayan Mukherji’s directorial ‘Brahmastra’, alongside rumoured beau Ranbir Kapoor and megastar Amitabh Bachchan.Produced under Karan Johar’s banner of Dharma Productions, the superhero movie will also feature Nagarjuna and Dimple Kapadia in pivotal roles.She also has Sanjay Leela Bhansali’s ‘Gangubai Kathiawali’, SS Rajamouli’s magnum opus ‘RRR’, and Shah Rukh Khan’s ‘Darlings’ in the pipeline. 

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