Washington [US], March 8 (ANI): A new study conducted by researchers at Washington State University has found new clues as to why night shift workers may be at increased risk of developing certain types of cancer compared to those who work regular daytime hours.
Findings suggest that night shifts disrupt natural 24-hour rhythms in the activity of certain cancer-related genes, making night shift workers more vulnerable to DNA damage while also causing the body’s DNA repair mechanisms to be mistimed to deal with that damage.
Published online in the Journal of Pineal Research, the study involved a controlled laboratory experiment that used healthy volunteers who were on simulated night shift or day shift schedules.
Though more research still needs to be done, these discoveries could someday be used to help prevent and treat cancer in night shift workers.
“There has been mounting evidence that cancer is more prevalent in night shift workers, which led the World Health Organization’s International Agency for Research on Cancer to classify night shift work as a probable carcinogenic,” said co-corresponding author Shobhan Gaddameedhi, an associate professor formerly with the WSU College of Pharmacy and Pharmaceutical Sciences and now with North Carolina State University’s Biological Sciences Department and Center for Human Health and the Environment.
“However, it has been unclear why night shift work elevates cancer risk, which our study sought to address.”
As part of a partnership between the WSU Sleep and Performance Research Center and the U.S. Department of Energy’s Pacific Northwest National Laboratory (PNNL), Gaddameedhi and other WSU scientists worked with bioinformatics experts at PNNL to study the potential involvement of the biological clock, the body’s built-in mechanism that keeps us on a 24-hour night and day cycle.
Though there is a central biological clock in the brain, nearly every cell in the body also has its own built-in clock. This cellular clock involves genes known as clock genes that are rhythmic in their expression, meaning their activity levels vary with the time of day or night. The researchers hypothesized that the expression of genes associated with cancer might be rhythmic, too, and that night shift work might disrupt the rhythmicity of these genes.
To test this, they conducted a simulated shift work experiment that had 14 participants spend seven days inside the sleep laboratory at WSU Health Sciences Spokane. Half of them completed a three-day simulated night shift schedule, while the other half were on a three-day simulated day shift schedule.
After completing their simulated shifts, all participants were kept in a constant routine protocol that is used to study humans’ internally generated biological rhythms independent of any external influences.
As part of the protocol, they were kept awake for 24 hours in a semi-reclined posture under constant light exposure and room temperature and were given identical snacks every hour. Every three hours a blood sample was drawn.
Analyses of white blood cells taken from the blood samples showed that the rhythms of many of the cancer-related genes were different in the night shift condition compared to the day shift condition. Notably, genes related to DNA repair that showed distinct rhythms in the day shift condition lost their rhythmicity in the night shift condition.
The researchers then looked at what the consequences of the changes in the expression of cancer-related genes might be. They found that white blood cells isolated from the blood of night shift participants showed more evidence of DNA damage than those of day shift participants.
What’s more, after the researchers exposed isolated white blood cells to ionizing radiation at two different times of day, cells that were radiated in the evening showed increased DNA damage in the night shift condition as compared to the day shift condition.
This meant that white blood cells from night shift participants were more vulnerable to external damage from radiation, a known risk factor for DNA damage and cancer.
“Taken together, these findings suggest that night shift schedules throw off the timing of expression of cancer-related genes in a way that reduces the effectiveness of the body’s DNA repair processes when they are most needed,” said co-corresponding author Jason McDermott, a computational scientist with the Pacific Northwest National Laboratory’s Biological Sciences Division.
The researchers’ next step is to conduct the same experiment with real-world shift workers who have been consistently on day or night shifts for many years to determine whether in night workers the unrepaired DNA damage builds up over time, which could ultimately increase the risk of cancer.
If what happens in real-world shift workers is consistent with the current findings, this work could eventually be used to develop prevention strategies and drugs that could address the mistiming of DNA repair processes.
It could also be the basis for strategies to optimize the timing of cancer therapy so that treatment is administered when effectiveness is greatest and side effects are minimal, a procedure called chronotherapy that would need to be fine-tuned to the internal rhythms of night workers.
“Nightshift workers face considerable health disparities, ranging from increased risks of metabolic and cardiovascular disease to mental health disorders and cancer,” said co-senior author Hans Van Dongen, a professor in the WSU Elson S. Floyd College of Medicine and director of the WSU Sleep and Performance Research Center.
“It is high time that we find diagnosis and treatment solutions for this underserved group of essential workers so that the medical community can address their unique health challenges.” (ANI)
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EMRAAN HASHMI’S BICEPS FOR ‘TIGER 3’ LEAVE FANS STUNNED
MUMBAI: It seems actor Emraan Hashmi is preparing hard for his role in ‘Tiger 3’. On Sunday, the ‘Jannat’ star took to Instagram to share a picture, wherein he can be seen sweating it out in the gym. “Just another arms day,” he captioned the post. Emraan’s physical transformation has left netizens in awe of his fitness. “This is amazing. Can’t wait to see you in ‘Tiger 3’, “ a user commented. “Killer looks,” another one wrote.
A few days ago, he had even shared a picture of himself where he flaunted his chiselled abs, hinting he has been going through a lot of fitness routines to achieve a look for the antagonist in the Salman Khan-starrer ‘Tiger 3’.
NUPUR SANON PENS EMOTIONAL POST FOR SISTER KRITI
NEW DELHI: Kriti Sanon’s younger sister Nupur Sanon shared an emotional post praising her sister for her performance in the much-acclaimed movie ‘Mimi’. After watching the movie, Nupur posted a couple of still images of Kriti who is essaying the titular role of a surrogate in the movie. Nupur termed her sister as “phenomenal” and revealed that she was blown away by Kriti’s performance which also made her shed tears.
“I always knew your true potential. But I was blown away by what I saw!! You did it, Mimi!! You were phenomenal! My Words won’t be able to describe what I felt. I have laughed and laughed and then cried and cried. There wasn’t even a single scene when I felt you weren’t 100 per cent Mimi !!” she wrote. She added “a mother who fell in love with her child instantly. I could see her forgetting her own dreams in a split second for her child. I could see her world revolving around her child. I could see her being territorial for him! I saw so many subliminal emotions in you Kriti!”
SHAHID KAPOOR SPORTS UBER COOL LOOK AHEAD OF DEBUT IN DIGITAL SHOW
MUMBAI : Actor Shahid Kapoor on Sunday flaunted his tattoo look ahead of his digital debut, which is directed by Raj Nidimoru and Krishna DK. Taking to Instagram, he posted a short video clip in which he can been seen with temporary tattoos on his neck. He also expressed his excitement about sharing screen space with Vijay Sethupathi and Raashi Khanna.
“Waiting on set call me soon @rajanddk … can’t wait to share the frame with @actorvijaysethupathi sorry @raashiikhanna I’ve got too used to having you around on set,” Shahid wrote on Instagram.
The yet-to-be-titled project is touted as a quirky drama thriller, which will release on Amazon Prime Video. Reacting to Shahid’s post, Raj and DK of ‘The Family Man’ fame commented: “Shot ready! Let’s roll.” Fans quite impressed by Shahid’s new look poured in their comments at Shahid’s post. “You look so hot,” a fan wrote. “Sexy look,” another social media user commented. Apart from Raj and Dk’s project, Shahid will also be seen in ‘Jersey’ — a Hindi remake of the 2019 Telugu hit of the same name.
KARTIK AARYAN TO STAR IN SHASHANKA GHOSH’S ‘FREDDY’
MUMBAI: Kartik Aaryan will star in an upcoming romantic thriller titled ‘Freddy’. The film, set to be directed by Shashanka Ghosh, will go on floors on August 1 in Mumbai this year. The movie will be produced by Ekta Kapoor and Jay Shewakramani. The romantic-triller is said to be packed with unpredictable twists and sharp turns. The characters in the movie are set to take the movie buffs on a dark and chilling roller-coaster ride, where the lines between love and obsession will blur. Speaking about the movie, an ecstatic Kartik said, “As an actor, I crave to explore different facades of entertainment and with ‘Freddy’, I’m venturing into an uncharted territory which is both exciting and intriguing in equal measures.”
The actor also said that he is looking forward to bringing the romantic thriller to life. He added, “I look forward to dwell in the world of Freddy and bring alive this dark romantic thriller. It also marks my first collaboration with a visionary like Ekta Kapoor and creatives forces like Jayu and Shahshanka. Couldn’t have asked for a better team on this new journey.”
Shashanka, who has helmed films like ‘Khoobsurat’ and ‘Veere Di Wedding’, also spoke about the upcoming project and said it is going to be one of the “best thrilling cinematic experiences” for the viewers. The director said, “As a filmmaker, there is a lot to play with the genre, like a thriller. I am more than excited to work with an incredible team on a project as inspiring as Freddy. I am sure that the film is going to be one of the best thrilling cinematic experiences for the audience across the nation.”
Ekta Kapoor said, “I’m thrilled to have Kartik on board. His choices of subject have always been unique and this one is no different. I’m excited to take the audience into this dark, delicious world. Collaborating with Jayu makes it even more special!”
Jay said, “It is the first time I am collaborating with Ekta and Kartik on a film and for it to be on a script like this, makes it all the more exciting! Freddy is a script we worked on incessantly and we can’t wait for Shashanka to bring to life these crazy characters.”‘Freddy’ marks Ekta and Shashanka second film after the hit flick ‘Veere Di Wedding’.
AYUSHMANN SHARES EXPERIENCE OF SINGING TRACK FOR WIFE TAHIRA’S FILM
MUMBAI: Actor Ayushmann Khurrana, who is also a singer, has once again swooned viewers with his voice in his wife and filmmaker Tahira Kashyap’s latest film ‘Quaranteen Crush’.
Taking to Instagram, Ayushmann shared the song’s video and revealed that he composed and wrote ‘Kinni Soni’ along with his college friends — Sameer Kaushal and Gurpreet Saini.
“Wrote and composed this butterflies inducing song with Sameer Kaushal and Gurpreet Saini for Tahira’s lovely short film #QurantineCrush which comes under #FeelsLikeIshq. Loved collaborating with my college friends after so long. Felt like we were back in college during our late night jam sessions in Chandigarh winters,” he posted.
Singer Jonita Gandhi has given English vocals to the song. “Thank you Jonita for the angrezi vocals,” Ayushmann added. For the unversed, ‘Quaranteen Crush’ is a part of the just-released Netflix anthology ‘Feels Like Ishq’. The short movie revolves around the concept of a teenage crush and friendship during the pandemic.
Tahira even posted a short note on Instagram thanking Ayushmann for giving her ‘Kinni Soni’ song. “The song we were waiting for #kinnisoni..An integral part of my short #quaranteencrush that is a part of #feelslikeishq. This song really inspired me to create some magical moments between nimmi and Maninder on their terrace! Thank you @ayushmannk for giving me the song, thank you @s_a_m_k28 and @ghuggss for creating magic with it and thank you @jonitamusic for the mesmerising vocals, and thank you @gazaldhaliwal for this sweet script,” she wrote.
Meanwhile, on the film front, Ayushmann is busy shooting for ‘Doctor G’ in Bhopal, Madhya Pradesh. The movie also stars Rakul Preet Singh and Shefali Shah..
PRABHAS’ ‘RADHE SHYAM’ TO RELEASE ON 14 JANUARY
MUMBAI: Prabhas’ most anticipated film ‘Radhye Shyam’ has finally got a release date. It will arrive in theatres on January 14, 2022.
On Friday, Prabhas took to Instagram to share the update with his fans. “Can’t wait to watch my romantic saga, ‘Radhe Shyam’, which has a brand new release date — 14th January, 2022 worldwide,” he wrote.
Along with it, Prabhas shared a new poster of the film, wherein he can be seen all decked up while walking on the streets of Europe.
For the unversed, ‘Radhe Shyam’, a multi-lingual film, is helmed by Radha Krishna Kumar, and it features actor Pooja Hegde as well. Pooja, too, expressed her excitement about the film’s release date as it is debuting on the auspicious occasion of Makar Sankranti. “Woke up to this surprise. Sakranti has been lucky for me..fingers crossed for this epic love story,” she wrote on Instagram Story. ‘Radhe Shyam’ is produced by Bhushan Kumar, Vamsi and Pramod.
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