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Healthy people infected with COVID-19 for sake of science should be paid, experts suggest

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Washington [US], February 5 (ANI): Multidisciplinary team of international experts suggests that healthy people volunteering to be infected with SARS-CoV-2, in order to help scientists better understand how to tackle the virus, should receive payment – if it is determined that these studies are otherwise ethical to proceed.
Those are the findings of a new peer-reviewed study published in the American Journal of Bioethics, which has assessed the ethics of paying participants to take part in so-called ‘Human Infection Challenge Studies’ (HICS).
Over the past few months, there has been vast media coverage and discussion about the first COVID-19 HICS in the world planned to begin in the UK later this year. This type of study can be particularly valuable for testing vaccines and can speed up the development of new vaccines.
Using HICS for a disease that can be fatal and currently lacks a cure is ethically controversial. Part of that controversy has to do with whether participants should be paid for such a risky endeavor and how payment might affect their consent.
Among the advocates of pursuing COVID-19 challenge, trials is the organization, 1Day Sooner.
1Day Sooner sponsored the report on which the new study is based, seeking an independent assessment of whether and how much people should get paid to take part in challenge trials.
The international research team from the UK, US, and Canada does not necessarily endorse the use of HICS for COVID-19. But if HICS proceed, their findings reflect that not only should participants be paid, but their payment should be “substantial”.
The research team – including experts in bioethics, economics, science, medicine, and law, as well as two individuals expressing interest in participating in SARS-CoV-2 HICS – created a framework for scientists to follow in order to ethically assess payments for people taking part in HICS.
They also looked at payment in similar studies, but noted the difficulty of finding out this information.
“Our work was spurred by concerns that payment for SARS-CoV-2 HICS might require a novel ethical framework, which we ultimately determined to be unfounded,” states lead author Holly Fernandez Lynch, John Russell Dickson, MD Presidential Assistant Professor of Medical Ethics at the Perelman School of Medicine, University of Pennsylvania.
“Payment for HICS participation should be treated like payment in other clinical studies involving healthy participants,” she said.
“High offers of payment are sometimes met with scrutiny and concern, but it can be ethically appropriate to offer substantial payment for research participation and we have to consider that low payment also raises significant ethical concerns,” she added.
“SARS-CoV-2 HICS should not be allowed to proceed in any setting in which there have not been adequate provisions made for compensating research-related harms, as well as other efforts to minimize risk and promote social value,” Professor Fernandez Lynch, who is a lawyer and bioethics expert, adds.
“Our hope going forward is that our analysis will serve both to ease concerns about payment in these studies, should they proceed, and to advance the broader project of ensuring ethical payment to participants in all clinical research,” added Lynch.
The framework the team has developed is split into two parts. The first focuses on three main motives for payment: ‘reimbursement’ (for out-of-pocket expenses), ‘compensation’ (which includes payment for time, burden, inconvenience of isolating, etc.), and ‘incentive’ (to broaden the range of individuals willing to consider participation).
The second part considers appropriate compensation in the event any harm materializes – ranging from injury to death.
In developing the framework, the team paid special attention to public trust, acknowledging that “research payments could affect public trust in several ways.”
Ultimately, they conclude that “the best way to promote trust in HICS is by helping the public understand why this design can be both scientifically important and ethically acceptable”.
“HICS can proceed only when strict research and ethical standards are satisfied,” said co-author Thomas Darton, from the Department of Infection, Immunity and Cardiovascular Disease at The University of Sheffield.
Dr Darton is a HICS researcher, although he does not work with the SARS-CoV-2 virus.
He states: “If the risks associated with these studies are unreasonable in relation to their potential benefits, payment for participation cannot help achieve ethical acceptability. But if the research is otherwise ethical, it doesn’t become unethical simply because payment is offered.”
Another factor the team considered is whether COVID-19 HICS would be “uniquely risky” and how that should influence payment levels. Ultimately, they concluded that “the ethical concerns about payment for these studies are the same as those for payment in all clinical research”.
“Although certainly relevant to considerations regarding the ethical acceptability of HICS, including the importance of planning for research-related harm, heightened risks do not support adopting a novel framework for HICS payment as compared to other types of research,” adds co-author Emily Largent, the Emanuel and Robert Hart Assistant Professor of Medical Ethics at the Perelman School of Medicine, University of Pennsylvania.
Limitations of the project include the team’s perspectives being “limited to the Global North”. They state, therefore, that additional considerations may be relevant when research is conducted elsewhere.
The team also declined to identify a payment amount or even a range that would be appropriate for HICS or SARS-CoV-2 HICS. “Stakeholders must take the final step between conceptual guidance and actual payment offers on their own,” the paper concludes.
“This means that there may be several different payment offers that could be justified, but the framework can help determine which offers are ethically appropriate,” said Professor Fernandez Lynch. (ANI)

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ADITYA TREATS FANS WITH AN IMPROMPTU MUSIC PERFORMANCE

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NEW DELHI: Aditya Roy Kapur made impressed his fans with his solo guitar performance.

Well, there’s not an ounce of doubt that Aditya happens to be one of the most loved stars. Now that the actor is shooting for his upcoming actioner ‘Thadam’ remake in Delhi, fans are thronging to catch a glimpse of him. Much to their excitement, the handsome and endearing actor decided to treat them with his magical voice.

Aditya’s impromptu show has elevated the excitement for his upcoming music album. For the unversed, just recently, the speculation around his music venture did rounds on social media. Meanwhile, the action hero is making noise for headlining the much anticipated ‘Thadam’ remake and essaying a double role for the first time. Aditya will also star in another out-and-out action drama ‘OM’.

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TAMANNAAHA MONG TOP 10 INFLUENTIAL SOCIAL MEDIA STARS IN SOUTH

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MUMBAI: The lines between regional cinema and mainstream films are blurring day by day. With the influx of more regional content pan-India, South Indian actors boast a massive fan following across the nation. Calculating their Instagram Influence using various metrics, Forbes India has released the Top 30 Most Influential South Actors on social media.

Touted as the rare combination of a superstar and a fine artist, Tamannaah has bagged the 10th spot on the list. With more than nine million followers on Instagram, the superstar is easily the most influential celebrity on the internet.

While talking about the same, Tamannaah said, “social media has become an integral part of all our lives, and it is a great platform to have an interaction with all my fans who have supported me in my journey. It is a special feeling to be listed as the Most Influential Social Media Star because it is a space that I share with my fans and followers.”

The top ten list also features Rashmika Mandanna, Vijay Deverakonda, Yash, Samantha, Allu Arjun, Dulquer Salmaan, Pooja Hegde, Prabhas, and Suriya.

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AYUSHMANN’SSOCIO-POLITICAL THRILLER ‘ANEK’S’ RELEASE DATE ANNOUNCED

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MUMBAI: 31 March 2022 has been locked as the release date for Ayushmann Khurrana’s film ‘Anek’.

Directed by Anubhav Sinha, ‘Anek’ is set against the geopolitical backdrop of Northeast India. It’s the second collaboration of Ayushmann with Sinha after ‘Article 15’. Giving a few details about his movie, Ayushmann said, “It’s only once in a while that an actor comes across a story that makes him jump out of his comfort zone. While I have always backed novel stories, Anek pushed me to perform with a renewed zest.”

He added, “It’s the kind of script that drives a person to give it your all. I am so proud that we’ve made a film like this and even more fortunate that I got the chance to headline it. It’s the kind of new-age cinema that I believe in and I am thankful to Anubhav Sir for choosing me to tell this special story.”

According to Sinha, it’s quite a challenge to make ‘Anek’. “It was a challenging film to write and a difficult one to make. We shot it in rough terrain but what makes it special is that the takeaway was so gratifying. It was a delight to work with Ayushmann again who with his depiction of Joshua breathed life into the story,” he said.

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NEW FILTER UNVEILED ON PRABHAS’ BIRTHDAY

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MUMBAI: Prabhas’ fandom knows no boundaries. The star is a global icon and enjoys a massive fan base. It’s that time of the year when the craze and love for him exceed any and every parameter, it’s Prabhas’ birthday. His fans do all sorts of surprising stuff to celebrate him and this year is no different. Ahead of his birthday, a new filter on Instagram has been unveiled. The filter has the words, ‘Global Prabhas Day’ written and plays a piece of soft and mellow music which is from the teaser of ‘Radhe Shyam’, as a portrait design comes on the screen and a little snowfall accompanies the same.

From Baahubali thalis to gigantic posters, to getting tattoos of Prabhas and more, his fans have always shown their love for the star. His Vikram Aditya from ‘Radhe Shyam’ got a new poster unveiled recently and a teaser of his character intro is all set to be released on his birthday. He will star in ‘AdiPurush’, ‘Salaar’, and Deepika Padukone starrer ‘K’.

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A CURTAIN RAISER TO ITALIAN EMBASSY CULTURAL CENTRE’S FELLINI RETROSPECTIVE

Murtaza Ali Khan

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Italian Embassy Cultural Centre is hosting a week-long Federico Fellini retrospective in collaboration with the India Habitat Centre. As part of the retrospective, eight of Fellini’s best-known films will be screened starting with his 1973 Academy Award-winning masterpiece ‘Amarcord’ on 23 October 2021. Along with introducing each of the eight films ahead of their respective screenings at the India Habitat Centre, I will also be introducing Fellini to the audiences while touching upon the importance of his films in India.

The legendary master Italian filmmaker Federico Fellini is not just recognised as one of the greatest and most influential filmmakers of all time but also as a great humanist whose lifelong work stands as a testament to his love for telling universally relevant stories about common people and life in Italy. Despite his origins in Italian Neorealism as a screenwriter for the luminary Italian director Roberto Rossellini, Fellini gradually emerged out of his shadows to carve a niche for herself with films like ‘The White Sheik’ (1952), ‘I Vitelloni’ (1953), ‘La Strada’ (1954), ‘Il Bidone’ (1955), and ‘Nights of Cabiria’ (1957). And then he took a huge leap with ‘La Dolce Vita’ (1960). Not many filmmakers in the world have succeeded in taking such a gigantic leap between films like the one Fellini took with ‘La Dolce Vita’.

But what did he do after it? He made ‘8½’ which is another major leap (it’s something that is unheard of except when maybe Ingmar Bergman made Persona). With ‘8½’, Fellini catapulted himself to an entirely different level of stardom altogether. The film in many ways also perpetuated the wide usage of the term ‘Felliniesque’ which would become synonymous with any kind of extravagant, fanciful, even baroque imagery in cinema—a sort of a superimposed dreamlike or hallucinatory imagery upon ordinary situations. Contemporary filmmakers like Tim Burton, Terry Gilliam, Emir Kusturica, and David Lynch have cited Fellini’s influence on their work. Fellini’s influence on Indian cinema is most evident in the works of Indian filmmakers like Mani Kaul (director of films like ‘Duvidha’, ‘Uski Roti’, ‘Nazar’, ‘The Cloud Door’, etc) and Kumar Shahani (the director of films like ‘Maya Darpan’, ‘Tarang’, and other movies)

‘Amarcord’, the first film to be screened as part of the retrospective, tells the story about Titta, an adolescent boy growing up among an eccentric cast of characters in a village near the ancient walls of Rimini in 1930s Fascist Italy (Rimini was where Fellini was born and the political turmoil during the rule of the Fascist regime in Italy also had a profound influence on Fellini’s life and work). The title basically translates to “I Remember” and aptly so. For, like many films of Fellini’s, ‘Amarcord’ is autobiographical in nature at so many levels. In fact, the character of Titta is based on Fellini’s childhood friend from Rimini who went on to become a lawyer. The two remained good friends all their lives. It is perhaps the last of Fellini’s undisputed masterworks. Even though Fellini would continue to make important films but ‘Amarcord’ in many ways is the last of his films to receive universal acclaim. It is also the last Fellini film to win the Oscar for the Best Foreign Language Film. The film is particularly noted for its criticism of Fascism as well as the Catholic Church but its comical tone cuts Fellini the slack to unleash a strong critique.

The romantic comedy ‘The White Sheik’, which will be screened on 24 October, follows Ivan and Wanda who visit Rome for their honeymoon. However, when Wanda suddenly disappears to find the White Sheik, the hero of a soap opera, Ivan struggles to hide it from his family who wants to meet his missing bride.

The third film to be screened as part of the retrospective on 27 October is ‘I Vitelloni’ which presents a character study of five young men at crucial turning points in their lives in a small town in Italy. One of the Italian maestro’s most imitated films, ‘I Vitelloni’ is said to have inspired directors like Martin Scorsese, George Lucas, Phillip Kaufman, Barry Levinson, Joel Schumacher, Juan Antonio Bardem, Marco Ferreri, and Lina Wertmüller, among others.

The next film on the lineup is ‘Il Bidone’ which follows a group of swindlers who dress up as clerics and con poor farmers out of their savings. It will be screened on the 28 October followed by ‘Nights of Cabiria’ on 29 October and ‘La Dolce Vita’ on 30 October. On the final day of Retrospective, not one but two films will be screened: ‘8½’ and ‘Fellini Satyricon’.

The Federico Fellini retrospective was originally scheduled to take place last year, marking the centenary celebrations of the master filmmaker, who was born in Rimini, Italy in 1920. But, the retrospective had to be delayed by a year owing to the Covid-19 pandemic.

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NEW STRATEGIES TO AMP UP YOUR INTERIORS IN THE NEW NORMAL

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The Coronavirus pandemic has created a new normal which has merged work with the living space. In these times, adding that extra ‘oomph’ can provide that change of environment you were looking for within your walls! Kshitij Mirania of Mirania Luxury Living shares those eye-catching strategies to amp up your interior game:

KINDLE WITH KITCHEN

Kitchen interiors are full of possibilities from hardwood to those modern cabinets. Replace or refinish those worn-out ones for a simply a new look and if modernising is the goal, bring in those glass doors and show off the shelving your nicest pieces!

CHANGE OF CURTAINS

Curtains has been named the underdog by many designers and for all the right reasons! It has the power to change the tone of the room, from stopping that extra heat to enter the room while lighting it up with colour to providing it the quick and colour it was missing. Finding the right curtains which match with the aesthetics of the room will surely be the easiest way to create a new environment without changing much.

ASTOUND WITH CARPETING

Room seems bigger with added warmth and texture? Well, the secret ingredient is that new carpet. Warm ones for the winter while lightweight is summer, carpet is an all-year accessory which will lift up your area. Since it is easy to store, think of it as an investment while purchasing as it will be something which can last you for many years to come.

STYLE-UP SURFACES

Flat, vertical and organic: the unbeatable arrangement for your coffee table. Add a stack of books with those gorgeous vases or sculptures and give it the finishing touches with flowers and plants and the work is done! All you have to do now is simply watch as those three ingredients come together to give your table that extra zing!

LIVEN UP THOSE WALLS

It is time to take out those old family photos and introduce them to the empty spaces on your walls! It will take you down the memory lane of those good-old-days while also providing a new look for the entire space with much ease. A two for one deal!

REPAINT-RENEW

Sometimes all you need is a small bottle white lacquer paint to change the colour palette of your living space. It will do miracles for those shabby, chipped out furniture you don’t know what to do with. Add that with PU paint for metals and watch your interiors come to life!

OLD COUCH, NEW LOOK

Why buy a new sofa when you can give the old one a makeover! The intention to change the colour can simply be satisfied with a slipcover and if the desire is to give it that extra colour then look no further from pillows and some knit throws. These small things will give you the effect you have wanted without cutting a hole in your pocket.

Kshitij Mirania is Partner and Head of Mirania Luxury Living (MLL).

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