Washington [US], March 4 (ANI): Green tea is already known for its antioxidant properties, which aid in immunity boosting and weight loss, but did you know that it can also prove beneficial for the facial development of children with Down syndrome?
According to a new study, green tea supplements modulate facial development in children with Down syndrome. The study, led by Belgian and Spanish researchers, was published in Nature Scientific Reports.
The researchers observed that the intake of green tea extracts can reduce facial dysmorphology in children with Down syndrome when taken during the first three years of life.
Additional experimental research in mice confirmed the positive effects at low doses. However, they also found that high doses of the extract can disrupt facial and bone development. More research is needed to fully understand the effects of green tea extracts and therefore they should always be taken under medical supervision.
Down syndrome is caused by the presence of a third copy of chromosome 21, leading to an overexpression of the genes in this region and resulting in a number of physical and intellectual disabilities. One of the genes, DYRK1A, contributes to altering brain and bone development in people with Down syndrome. The green tea compound EGCG (epigallocatechin-3-gallate) is known to inhibit DYRK1A activity, although it also has other mechanisms of action. Previous research has shown the potential of EGCG to improve cognition in young adults with Down syndrome.
In a new study, researchers analysed the effect of green tea supplements on facial development in Down syndrome. In the experimental part of the study, the EGCG supplements were tested in mice at different dosages.
In the second part of the research, they did an observational study on children with and without Down syndrome. This work, led by the Centre for Genomic Regulation (CRG), European Molecular Biology Laboratory (EMBL) and the University of Barcelona in Spain, and KU Leuven in Belgium, is an international effort involving researchers from the University of Central Florida, La Salle – University Ramon Llull, and IMIM – Hospital del Mar Medical Research Institute.
For the mouse study, carried out at KU Leuven, the researchers started the treatment before birth, while the pups were developing in the wombs of their mothers, by adding either a low or a high dose of green tea extracts to their drinking water. “The low dose treatment had a positive effect on mice that are a model of Down syndrome,” Professor Greetje Vande Velde (KU Leuven) commented, co-lead author of the study.
Velde added, “Sixty percent of them showed a facial shape similar to the control group.”
“The high dose treatment, however, generated very mixed results, and even disrupted normal facial development in some cases, causing additional dysmorphology. This occurred in all mice, in the model of Down syndrome as well as in the control group,” Velde further said.
The observational study was set up in Spain and also included participants from North America. 287 children between 0 and 18 years participated, including children with Down syndrome who did (n = 13) or didn’t (n = 63) receive EGCG supplementation. The treated group was all self-medicated and didn’t follow a prescribed protocol.
“All participants were photographed from various angles to create a 3D model of their faces,” explained Neus Martinez-Abadias, professor at the University of Barcelona and co-lead author of the study.
Martinez-Abadias added, “We use 21 facial landmarks, and the distances between them, to compare the faces of the participants. In the youngest group between 0 and 3 years, we observed that 57 percent of the linear distances are significantly different when you compare the faces of children with Down syndrome that never received the treatment to those of children that do not have Down syndrome. For babies and toddlers who did receive EGCG treatment, this difference was much smaller, only 25 percent. After green tea supplementation, the facial dysmorphology decreases and the children with or without Down syndrome look more alike.”
“We didn’t identify a similar effect in the adolescent group. Even when treated with green tea extracts, children with Down syndrome still show a difference of more than 50 percent compared to the control group. These findings suggest that the green tea supplements only affect facial development when they are administered in the early stages of life when the face and skull are rapidly growing,” Martinez-Abadias said.
Despite the potential benefits we observed, we must handle these findings with caution considering they are preliminary and based on an observational study,” Professor Vande Velde warns. “Much more research is necessary to evaluate the effects of EGCG-containing supplements, the appropriate dose and their therapeutic potential in general. We also need to take into the account possible effects on other organs and systems, not just on the development of the face. This requires first more basic research in the lab with mice, and then clinical studies with more participants and controlled use of these supplements.”
“Despite the potential benefits we observed, we must handle these findings with caution considering they are preliminary and based on an observational study,” Professor Vande Velde warned. (ANI)
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MICHAEL KEATON TO RETURN AS BATMAN IN UPCOMING ‘THE FLASH’ MOVIE
WASHINGTON [US]: American actor Michael Keaton’s fans now have a reason to rejoice as the actor is reprising his role as Batman/Bruce Wayne in the upcoming movie ‘The Flash.’
Fox News quoted a report by The Wrap as stating that Keaton’s talent agency, ICM Partners, confirmed his participation in the Andres Muschietti-directed DC Comics superhero film. Muschietti confirmed production kicked off in London on Monday in an Instagram post. The 69-year-old actor first played the Caped Crusader in Tim Burton’s 1989 hit ‘Batman,’ and then again in the 1992 film ‘Batman Returns.’
As reported by Fox News, Ezra Miller is set to reprise his role as Barry Allen/The Flash. Fans were introduced to him in ‘Justice League’ in 2017. Sasha Calle, best known from ‘The Young and the Restless,’ will play Supergirl.
Back in December, Keaton sent fans into a frenzy when he told Deadline he was concerned about COVID-19 safety and said he may not do the movie.
‘The Flash’ is slated to be released on November 4, 2022. — Correspondent
AKSHAY REPLACES KARTIK AARYAN IN KARAN JOHAR’S ‘DOSTANA 2’?
NEW DELHI: Days after actor Kartik Aaryan was allegedly thrown out of Karan Johar’s Dostana 2, the latest gossip doing the rounds is that Akshay Kumar will be onboard the project.
While nothing has been confirmed yet, rumours suggest that Akshay Kumar has been roped in for Dostana 2 in place of Kartik Aaryan. According to a report, sources have claimed that Dharma Productions has requested Akki to join the film as it’s a ‘tricky situation’ for the makers with no lead in sight.
Quoting sources, the publication has reported that Karan Johar has personally requested the superstar to join the film and help him sail through as huge money is involved in it already. And in all probabilities, Akshay Kumar is likely to give his nod for Dostana 2.
Dostana 2 was announced in 2019 by Karan Johar.
ADITI RAO HYDARI SHINES AS PRIYA SHARMA IN ‘GEELI PUCCHI’
NEW DELHI: Making waves with her amazing performances, Aditi Rao Hydari has truly established herself as one of the most bankable and versatile movie star in the Indian entertainment industry. Known for her seamless act in both, commercial- mainstream cinema and content-driven films, the stunner is a popular name not just in the Hindi film industry, but in Tamil, Telugu and Malayalam as well. Currently, receiving immense love for her incredible performance in the Netflix anthology ‘Ajeeb Daastaans’, Aditi has truly outdone herself as Priya Sharma in ‘Geeli Pucchi’.
‘Ajeeb Daastaans’ has been making headlines ever since it dropped on the OTT platform. Titled ‘Geeli Pucchi’ and directed by Neeraj Ghaywan, the film features Rao Hydari portraying the role of Priya Sharma, where she’s seen sharing a great chemistry with co-star Konkana Sen Sharma. The film showcases the story about two women coming from different casts and backgrounds, and how they eventually finding refuge in each other’s company.
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MUMBAI: Back to spending time at home amid the coronavirus-induced lockdown, Bollywood star Jacqueline Fernandez on Wednesday posted a stunning monochromatic photo from her home, urging people to stay safe.The ‘Kick’ actor posted a gorgeous picture on Instagram of herself resting in a chair. The picture shows the ‘Aladdin’ actor in a thigh-length jumpsuit and a messy bun. She is seen seated in her room taking rest during the lockdown.
Fernandez captioned the post as “Back to this.. stay safe everyone (and added a joined hands emoticon).”
Celebrity followers including Vaani Kapoor and more than 4.9 lakh fans liked the post on the photo-sharing platform, while many chimed into the comments section and dropped red heart and fire emoticons as they adored the lovable photo.
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MUMBAI: Amazon Prime Video, unveiled the official trailer of the all-new Amazon Original Series ‘LOL- Hasse Toh Phasse’. This local edition of the International Amazon Original Series LOL, will unite an eclectic group of comedians who have left their own indelible mark on India’s comedy landscape. Aadar Malik, Aakash Gupta, Aditi Mittal, Ankita Shrivastav, Cyrus Broacha, Gaurav Gera, Kusha Kapila, Mallika Dua, Sunil Grover and Suresh Menon, under the vigilant watch of hosts Arshad Warsi and Boman Irani will face their toughest challenge yet!
Perhaps for the first time, it’s not just their sense of humor but also their endurance which will be tested as they battle it out for six consecutive hours, to make the others in the house laugh, while maintaining a poker face themselves! The goal is to be the last one laughing in the room, and the person who keeps a straight face the longest will eventually win the game. Prime Members in Indian and across 240 countries and territories can binge-watch the show starting 30th April, 2021 exclusively on Amazon Prime Video.
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NEW DELHI: Bollywood star Madhuri Dixit recently became the latest addition to the viral ‘Bajre Da Sitta’ trend. The actor shared a gorgeous video of her performing to the popular song and giving priceless expressions.Madhuri took to her Instagram handle and shared a short clip in which she performed the viral song, flaunting her pre and post glow up looks. She captioned the post as, “On trend with #BajreDaSitta.” In the video shared by the 53-year-old actor, she could be seen lip-syncing to the song while sitting in her green room right before her makeover. Later in the clip, after the star’s dramatic transformation, she is seen clad in a light and dark pink lehenga. Madhuri also wore drop diamond earrings and a necklace, with her hair tied into a bun.
Meanwhile, on the work front, the ‘Dhak-Dhak’ girl of Bollywood will be debuting in the digital world through the suspenseful family drama series by Netflix titled ‘Finding Anamika’. The plot of the series revolves around the story of a global superstar, wife, and mom who suddenly vanishes without a trace. As police and loved ones search for answers to her disappearance, her perfectly crafted facade is stripped away, revealing hidden truths and painful lies in the life of an iconic actress.
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