A new study has shown that several common chemicals, including ingredients in consumer products and drinking water contaminants, could increase the risk of breast cancer by causing cells in breast tissue to produce more of the hormones estrogen or progesterone. The findings of the study appeared in the journal ‘Environmental Health Perspectives’. Every day, people are exposed to synthetic chemicals through the products they use. For many of these chemicals, the health effects are unknown.
However, this study has found the adverse effects of these chemicals and how it may increase the risk of breast cancer. “The connection between estrogen and progesterone and breast cancer is well established,” said co-author Ruthann Rudel, a toxicologist and research director at Silent Spring Institute. “So, we should be extremely cautious about chemicals in products that increase levels of these hormones in the body,” added Rudel. For instance, in 2002, when the Women’s Health Initiative study found combination hormone replacement therapy to be associated with an increased risk of breast cancer, women stopped taking the drugs and incidence rates went down.
“Not surprisingly, one of the most common therapies for treating breast cancer is a class of drugs called aromatase inhibitors that lower levels of estrogen in the body, depriving breast cancer cells of the hormones they need to grow,” said Rudel. To identify these chemical risk factors, Rudel and Silent Spring scientist Bethsaida Cardona combed through data on more than 2000 chemicals generated by the US Environmental Protection Agency (EPA)’s ToxCast program.
The goal of ToxCast is to improve the ability of scientists to predict whether a chemical will be harmful or not. The program uses automated chemical screening technologies to expose living cells to chemicals and then examine the different biological changes they cause.
Reporting in the journal Environmental Health Perspectives, Rudel and Cardona identified 296 chemicals that were found to increase estradiol or progesterone in cells in the laboratory. 71 chemicals were found to increase levels of both hormones. The chemicals included ingredients in personal care products, chemical flame retardants in building materials and furnishings, and a number of pesticides.
The researchers don’t yet know how these chemicals are causing cells to produce more hormones. It could be the chemicals are acting as aromatase activators, for instance, which would lead to higher levels of estrogen, said Cardona. “What we do know is that women are exposed to multiple chemicals from multiple sources on a daily basis, and that these exposures add up.” The Silent Spring researchers hope this study will be a wake-up call for regulators and manufacturers in how they test chemicals for safety.
