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What is H3N2 Subclade K ‘Super Flu’ Affecting the US & Europe? Symptoms & Causes Explained

H3N2 Subclade K is also called the ‘Super Flu,’ is spreading across the US and Europe. Know about its symptoms, causes and how to protect yourself this flu season.

Published By: Amreen Ahmad
Last Updated: January 3, 2026 11:21:38 IST

‘Super Flu’ Subclade K: A rapidly spreading strain of influenza known as the ‘Super Flu’ is being monitored by health authorities in the US and Europe. Although the moniker may sound dramatic, experts say that the speed at which this variant is spreading and the unprecedented strain it is placing on the healthcare system during the current flu season are causes for concern.

What is the Super Flu

An influenza with H3N2 Subclade K is a genetically drifted variant of a long-circulating seasonal flu virus referred to as ‘Super Flu.’ This strain has quickly taken over several nations, contributing to what the US Centers for Disease Control and Prevention has called the worst flu season since 2017–18. The flu outbreak in the UK started earlier than any season since 2003–2004.

What is Subclade K Influenza & How is it Different from Other Flu Strains?

Subclade K is part of the H3N2 family, a group historically associated with tougher flu seasons. According to scientists, Small mutations make it better at dodging some pre-existing immunity and this leads to a higher number of cases. It is a surge not a particular severe symptom that presents a problem with this particular variant.

What are the Symptoms of Super Flu

  • Fever and Chills
  • Dry Cough
  • Sore Throat 
  • Headache
  • Sneezing 
  • Runny or Stuffy Nose
  • Body aches and muscle pain
  • Fatigue and weakness 
  • Shortness of breath or wheezing 
  • Vomiting or Diarrhea 

The Symptoms of Super Flu are generally similar to regular seasonal flu.

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How is the ‘Super Flu’ Spreading Across Countries

The strain was first identified in Australia, where it prolonged the flu season into summer months between January and November 2025 and recorded more than 457,000 confirmed influenza cases with the highest since flu reporting began in 2001. The virus then spread quickly to the United States, the United Kingdom, Canada, Japan and much of Europe.

In the US, New York reported over 71,000 flu cases in a single week in December, the highest weekly figure in more than 20 years. European health agencies and the NHS in the UK have also reported sharp rises in hospital admissions, among older adults and people with underlying conditions.

What are the Cause of Super Flu

  • Genetic Mutation of the H3N2 Virus: Subclade K has changes in its haemagglutinin protein that help it spread more easily.
  • Antigenic Drift: Small changes in the virus allow it to partially evade immunity from past infections or vaccines.
  • High Transmissibility: The virus spreads quickly through droplets when people cough, sneeze, or talk.
  • Low Population Immunity: Many people have limited protection against this new subclade, making outbreaks more likely.
  • Seasonal Factors: Cooler weather and indoor gatherings increase transmission.
  • Global Travel: Movement of infected individuals helps the virus spread across countries and continents.

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How to Protect Yourself from the ‘Super Flu’

  • Get your seasonal flu vaccine
  • Wash hands regularly or use sanitizer
  • Wear a mask in crowded indoor spaces
  • Avoid close contact with sick people
  • Cover coughs and sneezes
  • Disinfect commonly touched surfaces
  • Stay home if you feel sick
  • Eat well, sleep enough and exercise

How Effective Is the Flu Vaccine Against Subclade K?

Experts acknowledge that the current flu vaccine is not a perfect match for subclade K and data suggests it still offers a meaningful protection against severe illness. The studies indicate vaccine effectiveness of around 70 to 75% in children & adolescents and 30 to 40% in adults, comparable to recent H3N2 seasons. Health officials stress that vaccination continues to reduce hospitalizations and serious complications, even when infections occur.

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Disclaimer: This article is for informational purposes only. Consult a healthcare professional for medical advice or treatment regarding flu symptoms or exposure.

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The Daily Guardian is India’s fastest growing News channel and enjoy highest viewership and highest time spent amongst educated urban Indians.

© Copyright ITV Network Ltd 2025. All right reserved.