New York [US], February 13 (ANI): An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the ‘guardian of the genome’ for its ability to repair DNA damage or destroy cancerous cells.
Published in Nature Communications, a study of the direct interaction between p53 and the green tea compound, epigallocatechin gallate (EGCG), points to a new target for cancer drug discovery.
“Both p53 and EGCG molecules are extremely interesting. Mutations in p53 are found in over 50% of human cancer, while EGCG is the major antioxidant in green tea, a popular beverage worldwide,” said Chunyu Wang, corresponding author and a professor of biological sciences at Rensselaer Polytechnic Institute.
“Now we find that there is a previously unknown, direct interaction between the two, which points to a new path for developing anti-cancer drugs. Our work helps to explain how EGCG is able to boost p53’s anti-cancer activity, opening the door to developing drugs with EGCG-like compounds,” added Wang.
Wang, a member of the Rensselaer Center for Biotechnology and Interdisciplinary Studies, is an expert in using nuclear magnetic resonance spectroscopy to study specific mechanisms in Alzheimer’s disease and cancer, including p53, which he described as “arguably the most important protein in human cancer.”
P53 has several well-known anti-cancer functions, including halting cell growth to allow for DNA repair, activating DNA repair, and initiating programmed cell death — called apoptosis — if DNA damage cannot be repaired. One end of the protein, known as the N-terminal domain, has a flexible shape, and therefore, can potentially serve several functions depending on its interaction with multiple molecules.
EGCG is a natural antioxidant, which means it helps to undo the near constant damage caused by using oxygen metabolism. Found in abundance in green tea, EGCG is also packaged as an herbal supplement.
Wang’s team found that the interaction between EGCG and p53 preserves the protein from degradation. Typically, after being produced within the body, p53 is quickly degraded when the N-terminal domain interacts with a protein called MDM2. This regular cycle of production and degradation holds p53 levels at a low constant.
“Both EGCG and MDM2 bind at the same place on p53, the N-terminal domain, so EGCG competes with MDM2,” said Wang. “When EGCG binds with p53, the protein is not being degraded through MDM2, so the level of p53 will increase with the direct interaction with EGCG, and that means there is more p53 for anti-cancer function. This is a very important interaction.”
“By developing an understanding of the molecular-level mechanisms that control key biochemical interactions linked to devastating illnesses such as cancer and Alzheimer’s disease, Chunyu’s research is laying the groundwork for new and successful therapies,” said Curt Breneman, dean of the Rensselaer School of Science.
“EGCG Binds Intrinsically Disordered N-Terminal Domain of p53 and Disrupts p53-MDM2 Interaction” was published with support from multiple grants from the National Institutes of Health. At Rensselaer, Wang was joined in the research by Lauren Gandy, Weihua Jin, Lufeng Yan, Xinyue Liu, and Yuanyuan Xiao.
First author Jing Zhao is a former member of Wang’s lab, now on the faculty at China Agricultural University in Beijing, China. Co-first author Alan Blaney is an M.D.-Ph.D. student at Upstate Medical University.
Researchers also contributed from SUNY Upstate Medical Center; the University of Massachusetts, Amherst; New York University; the State University of New York at Binghamton; NYU Shanghai; and Merck Research Laboratories. (ANI)
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RADHIKA MADAN RECEIVES COVID-19 VACCINE SHOT
MUMBAI: Actor Radhika Madan informed her fans that she got vaccinated against the coronavirus on Wednesday, and also urged everyone to register for the same with a social media post. Taking it to her Instagram handle, Radhika shared a picture of herself getting vaccinated at a dispensary.
In the caption, she wrote, “One step at a time #Vaccinated”. She further urged everyone to get themselves registered for their shot and while adhering to all the precautions and discipline at the vaccination centres. “Wear double mask, sanitize your hands, maintain distance and don’t panic. Don’t forget to get a good night’s sleep the day before and stay well hydrated #FightCorona,” Radhika concluded.
Earlier stars like Salman KhanHema Malini, Anupam Kher, Johnny Lever, Saif Ali Khan, Kamal Haasan, Satish Shah and others had also received the vaccination shots. Bollywood actors are constantly striving to create awareness against COVID-19 as well as offering assistance in arranging necessities via their social media.
Imparting hope in these unprecedented times, celebrities have united to spread positivity and awareness pleading everyone to wear masks, maintain social distancing as well get vaccinated to help eradicate the virus.
ALT BALAJI’S HAI TAUBBA DEPICTS UNIQUE STORIES OF LOVE
MUMBAI: ALT Balaji’s Hai Taubba is a four-episode anthology drama. The series depicts society’s perception of these distinct individuals with their unique stories of love. It reminds viewers of how judgemental the world is and reminds a person to check themselves before judging another human being.
Gagan Anand started his career in the fashion industry as a designer and model. He has made his mark in the entertainment industry with major roles in major shows such as Ek Veer Ki Ardaas Veera, Bajirao and Ye Hai Mohabbatein. In the OTT space, he has been absolutely brilliant with shows like Fixerr under his belt. He will currently be seen in a major role in ALTBalaji’s brand new series, Hai Taubba as Nitin.
Gagan Anand exclusively spoke to The Daily Guardian and shared his excitement of being a part of Alt Balaji show.
How excited are you to be back on screen with Alt Balaji show Hai Taubba? How did you bag the role?
Balaji is like a family to me now, working with them since a long time is like working with your loved ones.
Hai Taubba is a story, which has all the emotions which one could feel, and after doing a few grey shades / character I am really excited to play this emotional one which has the same sex love story.
What does your character look like in the show Hai Taubba? How relatable it is?
I am playing Nitin’s character who is a masculine physiotherapist, looks like a strong alpha man but from inside he is really very emotional, falls for a taxi driver Amit. We will see an unsaid love story between them and the separation will make people cry.
You have done TV shows as well, how different was doing a show for OTT platform?
Yes, I have done TV shows as well and I felt, life gets monotonous while doing TV. And the content we created on web now a day really satisfies the hunger of creative minds. We play a lot of character in a short span of time and explore a lot.
How was the experience working with the co actors?
It was fun working with all of them. When you go outdoors for work, you enjoy more and spend a lot of time together while working and shooting, so you make friends, which is a good part of it. Even chilling in Goa after the packup was a great fun. Overall have some good memories of screen as well.
HANSAL MEHTA IS SUPER PROUD OF ‘OMERTA’
MUMBAI: Hansal Mehtas directorial ‘Omerta’ was released three years ago on Tuesday. He talked about the film and said Rajkummar Rao’s performance stands tall among their projects together. Hansal shared the poster on Instagram of the film and wrote: “3 years of #Omerta. A film I’m super proud of. A performance by Raj that stands tall in our work together.”
‘Omerta’ is a biographical crime drama that had Rajkummar essaying Ahmed Omar Saeed Sheikh, British terrorist of Pakistani descent. The film revolves around the 1994 kidnappings of Westerners in India.
Mehta had helmed ‘Scam 1992’ last year. He will be directing its second instalment ‘Scam 2003: The Curious Case Of Abdul Karim Telgi’.
PAYAL DEV OPENS UP ABOUT CROONING ‘DIL DE DIYA’ FROM SALMAN’S ‘RAADHE’
Singer Payal Dev sets the stage on fire with the super energetic song ‘Dil De Diya’ for Salman Khan upcoming movie ‘Raadhe’ featuring Jacqueline Fernandez. The song is composed by Himesh Reshammiya, sung by Payal Dev and Kamaal Khan, music produced by Aditya Dev and lyrics by Shabbir Ahmed.
Sharing her experience about singing this song exclusively with The Sunday Guardian, Payal says, “It’s an honour to sing for Himesh Reshammiya and we have previously collaborated on movies like ‘Happy Hardy’ and ‘Heer’. I’m a fan of his compositions which are unique and sure-shot hits. When he reached out to me for ‘Dil De Diya’, I was super excited as working with him and Salman Khan is always challenging and fun. The song is such a vibe that it gives a nostalgic feeling every time I hear it. When I got to know this song is for ‘Raadhe’ I was over the moon to be part of such a brilliant album. I am a huge fan of Salman. Post recording the song, he heard the song and really liked my voice and versatility. I’m thankful to Himesh and Salman for giving me this opportunity.” Currently, the singer is judging a singing reality show, IPML on Zee TV.
ABHISHEK BANERJEE WAS LIKE A BOUNCING BOARD FOR ME: NUSHRRATT BHARUCCHA
NEW DELHI: Nushrratt Bharuccha and Abhishek Banerjee were recently seen in ‘Ajeeb Daastaans’. The duo shared great chemistry on-screen in their film and Nushrratt revealed the reason behind the same. She shares, “It was truly a blessing that Abhishek Banerjee was cast in the ‘Ajeeb Daastaans’ alongside me. I have given so many auditions at his casting agency since the time I started my career, he would enact the scenes with me as my co-actor and give me the necessary critique. I could easily discuss my character and story with him.” Nushrratt adds, “He was like a bouncing board for me literally, where I could easily bounce off my ideas on how to enact a particular scene and he would also improvise along with me. While shooting for Khilauna, I could put in extra effort in my character with his help, because I could easily run my thoughts through him, and I knew he would give me honest feedback.”
JACQUELINE FERNANDEZ LAUNCHES YOLO FOUNDATION
MUMBAI: Jacqueline Fernandez, on Tuesday, announced the launch of her ‘You Only Live Once’ foundation to create and share stories of kindness amid the Covid-19 pandemic.
Taking to her Instagram handle, Jacqueline announced the launch of the YOLO Foundation; an initiative to create and share stories of kindness in these challenging times.
In the caption, Jacqueline wrote, “We have this one life, let’s do whatever we can to make a difference in this world!! I am proud to announce the launch of the YOLO Foundation; an initiative to Create and Share Stories of Kindness.”
She further added, “In these challenging times, the Yolo Foundation has partnered with several NGOs to help in whichever way we possibly can. Watch this space to know how you can contribute and make a difference to the lives around you #staysafe #spreadlove #helpothers”
Jacqueline had previously extended her help to people in rebuilding their houses post-flood relief and had also worked towards the nourishment of children during Covid-19. Meanwhile, on the work front, she has films like ‘Bachchan Pandey’, ‘Bhoot Police’, ‘Attack’, ‘Cirkus’, ‘Ram Setu’ in the pipeline.
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