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Study links diabetes during pregnancy with increased risk of heart disease

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Washington [US], February 1 (ANI): Women with a history of diabetes during pregnancy (gestational diabetes) are twice as likely by mid-life to develop calcium in heart arteries–a strong predictor of heart disease– even if healthy blood sugar levels were attained many years after pregnancy, according to new research.
The research was published today in the American Heart Association’s flagship journal Circulation.
Gestational diabetes, which is high blood sugar levels (glucose intolerance) first recognized during pregnancy, affects approximately 9% of U.S. pregnancies and up to 20% worldwide. After pregnancy, women who had gestational diabetes are at higher risk of developing prediabetes or Type 2 diabetes, conditions that are risk factors for cardiovascular disease.
Previous studies found a much higher risk of heart disease in women with a history of gestational diabetes who later developed Type 2 diabetes. However, it remained unclear whether heart disease risk among women with a history of gestational diabetes was lower for women who attained healthy glucose levels or who developed prediabetes in mid-life.
In 2018, the American College of Cardiology/American Heart Association Cholesterol Clinical Practice Guidelines specified that a history of gestational diabetes enhances women’s risk for artery build-up that leads to cardiovascular disease.
Using data from the multicenter, 30-year prospective Coronary Artery Risk Development in Young Adult (CARDIA) study, researchers investigated whether attaining healthy blood sugar levels after pregnancy would mitigate the increased risk of cardiovascular disease that is associated with a history of gestational diabetes.
“CARDIA is the first study to assess heart disease risk in women with a history of gestational diabetes compared to those without gestational diabetes according to their blood sugar levels many years later. Women with previous gestational diabetes had a twofold higher risk of coronary artery calcium if they maintained normal blood sugar levels, later developed prediabetes, or later were diagnosed with Type 2 diabetes many years after pregnancy compared to women without previous gestational diabetes who had normal blood sugar levels,” said Erica P. Gunderson, PhD, M.S., M.P.H., epidemiologist and senior research scientist in the Cardiovascular and Metabolic Conditions Section at Kaiser Permanente’s Division of Research in Oakland, California.
The CARDIA study enrolled more than 5,100 U.S. men and women who were aged 18-30 years at the beginning of the study in 1985. The new analysis includes approximately 1,100 women (49% Black women and 51% white women) without Type 1 or Type 2 diabetes who subsequently gave birth at least once during the 25-year study period, which ended in 2011. Blood tests were performed from before to after pregnancies at five-year intervals to determine if women had normal blood sugar levels, intermediate elevations in blood sugar levels (prediabetes) or they had developed overt Type 2 diabetes. Heart scans were performed to measure coronary artery calcium, a strong predictor for heart disease, at exams 15, 20 and 25 years after the baseline, the first exam of the study.
At the 25-year follow-up, the participants’ median age was 48 years old, and 12% of the women in the study had a pregnancy complicated by gestational diabetes. The prospective analysis found:
-Women with a history of gestational diabetes had a two-fold higher risk of coronary artery calcification whether they had healthy blood sugar levels, prediabetes or Type 2 diabetes.
-Attaining healthy blood sugar levels after pregnancy did not decrease the risk of developing cardiovascular disease in mid-life for women with previous gestational diabetes.
-Of women with previous gestational diabetes, 36% developed prediabetes and 26% developed Type 2 diabetes, compared to 35% and 9% of women with no history of gestational diabetes.
-25% of women with a history of gestational diabetes had some level of coronary artery calcium vs. 15% of women who never had gestational diabetes.
“We were surprised to discover that women with a history of gestational diabetes are at a significantly greater risk of heart artery calcification, even if they maintain normal blood sugar levels after pregnancy,” Gunderson said.
“Our findings represent a shift in this paradigm by showing that normal blood glucose after gestational diabetes is still related to higher coronary artery calcium risk,” the authors note.
“Risk assessment for heart disease should not wait until a woman has developed prediabetes or Type 2 diabetes,” Gunderson said.
“Diabetes and other health problems that develop during pregnancy serve as early harbingers of future chronic disease risk, particularly heart disease. Health care systems need to integrate the individual’s history of gestational diabetes into health records and monitor risk factors for heart disease, as well as the recommended testing for Type 2 diabetes in these women at regular intervals, which is critical to target prevention efforts.”
Limitations of the study include that researchers had no measurement of coronary artery calcium levels prior to pregnancy, and coronary artery calcium scores were used as a surrogate marker for heart disease risk not cardiovascular events. (ANI)

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ARJUN MATHUR TO ADARSH GOURAV: HERE’S LOOKING AT THE TOP THREE OTT NEWSMAKERS

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MUMBAI: The past few years have been a revelation for Indian cinema with the influx of OTT content. From handling an out-of-box idea to bringing forth a crucial issue in the limelight – our actors are going all out with their digital ventures!

While we saw some of the finest performances on the streaming platforms last year, there are a few names that define the space with their path-breaking performances, unconventional takes, and impeccable cinema sense. So, here’s rounding up the top four OTT newsmakers.

ARJUN MATHUR: You cannot have a list of the ground-breaking stars without Arjun Mathur. The international Emmy Award-nominated actor has pushed the boundaries with his non-conformist choices, like playing a gay wedding planner in Made In Heaven or shooting a show in a lockdown with The Gone Game. Now, he has Made In Heaven S2, Gone Game 2, Lord Curzon Ki Haveli, and Lionsgate Play’s next series.

PRATIK GANDHI: Pratik Gandhi became a household name with his blockbuster series, Scam 1992. The actor earned massive acclaim for his apt and flamboyant performance of Harshad Mehta. Later, he stunned the audience with his brave selections – Bhavai and Shimmy. Coming up next for the actor are Atithi Bhooto Bhava, Woh Ladki Hai Kahaan?, and Six Suspects.

ADARSH GOURAV: With his solid performance in The White Tiger, Adarsh Gourav has made it into everyone’s watchlist. The new-age actor bagged the BAFTA nomination for his performance and is all set to step into Hollywood with his next venture, Extrapolations, starring Meryl Streep. 

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PANDIT BIRJU MAHARAJ WAS MY GURU BUT ALSO MY FRIEND: MADHURI

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NEW DELHI: Behind every successful person, there are unfailing efforts of teachers. Kathak legend Pandit Birju Maharaj played the role of that guru in actor Madhuri Dixit Nene’s life.

After learning about the demise of Pandit Birju Maharaj, Madhuri, on Monday, took to Twitter and opened up about her relationship with him. “He was a legend but had a child like innocence. He was my guru but also my friend. He taught me the intricacies of dance and Abhinay but never failed to make me laugh at his funny anecdotes,” she wrote.

“He has left behind grieving fans and students but also left a legacy we will all carry forward. Thank you Maharajji for everything you taught me in dance along with humility, elegance and grace. Koti koti pranam,” she added.

Alongside the note, Madhuri posted a throwback picture of her doing mukhdas with Pandit Birju Maharaj. For the unversed, Pandit Birju Maharaj, who breathed his last on Monday, had worked with Madhuri in films like ‘Dil Toh Pagal Hai’, ‘Devdas’ and ‘Dedh Ishqiya’.

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Bollywood in awe of Pushpa & Allu Arjun

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Mumbai: Pushpa star Allu Arjun, the talk of the town, has absolutely impressed
his fans,audiences, actors in the South and also many bigwigs in Bollywood. The
stylish star with his emphatic performance has won the hearts of many in the Hindi
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the movie, reiterate what the stylish star has said in the film, ‘Pushpa is not flower,
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At a time when Allu Arjun has amassed a big fan following in
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Hindi actors are showing interest to act in his upcoming pan-India movies. It is also reportedly said that producers are looking
to get Hindi dubbing or remake rights of the icon star’s upcoming films as they feel he will dominate the cinema space now.
The passion Allu Arjun put into his Pushpa Raj character is
so evident that people are just captivated by him.

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LATA MANGESHKAR TO REMAIN UNDER SUPERVISION FOR A FEW MORE DAYS

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MUMBAI : Giving a health update regarding legendary singer Lata Mangeshkar, her doctor on Sunday shared that the megastar will still remain in the Intensive Care Unit (ICU), under the supervision of doctors for a few more days.

The Bharat Ratna recipient was admitted to Breach Candy Hospital in Mumbai last week and her treatment is still going on. The 92-year-old star is suffering from corona as well as pneumonia. Dr Pratit Samdani who is treating the veteran singer said that “Lata ji is still in the ICU, she still that is why she is kept under the supervision of the doctor in the ICU.” “Lata ji will remain under the supervision of the doctor for a few more days, it is difficult to say how many days it will last. No one is allowed to meet.” The doctor also said that there is a need for people to pray for her recovery.

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MOUNI ROY TO RETURN TO SMALL SCREEN AS A JUDGE ON REALITY SHOW

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MUMBAI : After working in films like ‘Gold’, ‘Made in China’, and the yet-to-be-released ‘Brahmastra’, actor Mouni Roy is back to the small screen — the place where she first made her acting debut. Mouni is all set to appear as a judge on ‘Dance India Dance Li’l Masters Season 5’. Talking about the same, she said, “For me, dance is an expression. It is an amalgamation of various art forms. I am incredibly excited to be a part of Dance India Dance Little Masters as a judge. I can’t wait to watch the young kids showcasing their talent on such a huge platform.”

Mouni started her acting journey with TV shows and rose to fame with supernatural ‘Naagin’. 

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KURUKKU VAZHI IS A CRIME THRILLER: SHIRA GAARG

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CHENNAI: What started as a surprising opportunity for actress Shira Gaarg to explore her passion became her career path once she started getting good reviews from reputed film critics for her role in her debut Tamil film Baby. Hailing from Bengaluru, Shira Gaarg was pursuing her college studies when a photoshoot caught the attention of director Balaji Sakthivel and his production team. They were looking for a fresh face for the movie Baby. She did not have any experience in acting then but after motivation from the director and support from her family she accepted the offer. Later after completion of her MBA she decided to take acting as her full time profession. Actress Shira Gaarg has recently completed the shoot for Tamil film titled Shot Boot Three directed by Arun Vaidyanathan and is currently shooting for her next movie Kurukku Vazhi directed by N.T. Nantha. In a candid conversation the actress avers, “Kurukku Vazhi is a crime thriller. It describes about what happens when people take short cut in life and how it would impact others. It is a very emotional role and the character has to go through mix of emotions. The story is about four people and what choices I make while dealing with them.” The film is produced by K Singh and A. Sharma. Apart from writing and directing the film, N.T. Nantha has also handled cinematography and composed the music. Apart from these projects, Shira Gaarg has also played the lead role in a Tamil web series Chewing Gum for Hotstar Network. She further added, “All my roles are unique and distinct. I am looking at playing meaty kind of roles. Fortunately the roles which I have played are all different and diverse.” 

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