Study found heart damage in more than half of COVID-19 patients discharged from hospital - The Daily Guardian
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Study found heart damage in more than half of COVID-19 patients discharged from hospital

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Washington [US], February 20 (ANI): Through a clinical study published in the European Heart Journal, scientists claim that around half of the patients studied have had their heart damaged subsequent to being hospitalised with severe COVID-19 and they showed elevated levels of a protein called troponin.
The injury was detected by magnetic resonance imaging (MRI) scans at least a month after discharge, according to new findings published Thursday in the European Heart Journal.
Damage includes inflammation of the heart muscle (myocarditis), scarring or death of heart tissue (infarction), restricted blood supply to the heart (ischaemia) and combinations of all three.
The study of 148 patients from six acute hospitals in London is the largest study to date to investigate convalescing COVID-19 patients who had raised troponin levels indicating a possible problem with the heart.
Troponin is released into the blood when the heart muscle is injured. Raised levels can occur when an artery becomes blocked or there is inflammation of the heart. Many patients who are hospitalised with COVID-19 have raised troponin levels during the critical illness phase, when the body mounts an exaggerated immune response to the infection.
Troponin levels were elevated in all the patients in this study who were then followed up with MRI scans of the heart after discharge in order to understand the causes and extent of the damage.
Professor Marianna Fontana, professor of cardiology at University College London (UK), who led the research together with Dr. Graham Cole, a consultant cardiologist at Imperial College London, said: “Raised troponin levels are associated with worse outcomes in COVID-19 patients. Patients with severe COVID-19 disease often have pre-existing heart-related health problems including diabetes, raised blood pressure, and obesity.”
“During severe COVID-19 infection, however, the heart may also be directly affected. Unpicking how the heart can become damaged is difficult, but MRI scans of the heart can identify different patterns of injury, which may enable us to make more accurate diagnoses and to target treatments more effectively,” added Fontana.
The researchers investigated COVID-19 patients discharged up until June 2020 from six hospitals across three NHS London trusts: Royal Free London NHS Foundation Trust, Imperial College Healthcare NHS Trust, and University College London Hospital NHS Foundation Trust.
Patients who had abnormal troponin levels were offered an MRI scan of the heart after discharge and were compared with those from a control group of patients who had not had COVID-19, as well as from 40 healthy volunteers.
“The recovering COVID-19 patients had been very ill; all required hospitalisation and all had troponin elevation, with around one in three having been on a ventilator in the intensive care unit,” said Prof. Fontana.
“We found evidence of high rates of heart muscle injury that could be seen on the scans a month or two after discharge. Whilst some of this may have been pre-existing, MRI scanning shows that some were new, and likely caused by COVID-19. Importantly, the pattern of damage to the heart was variable, suggesting that the heart is at risk of different types of injury,” he added.
“While we detected only a small amount of ongoing injury, we saw injury to the heart that was present even when the heart’s pumping function was not impaired and might not have been picked up by other techniques. In the most severe cases, there are concerns that this injury may increase the risks of heart failure in the future, but more work is needed to investigate this further,” he continued.
The function of the heart’s left ventricle, the chamber that is responsible for pumping oxygenated blood to all parts of the body, was normal in 89 per cent of the 148 patients but scarring or injury to the heart muscle was present in 80 patients (54 per cent).
The pattern of tissue scarring or injury originated from inflammation in 39 patients (26 per cent), ischaemic heart disease, which includes infarction or ischaemia, in 32 patients (22 per cent), or both in nine patients (6 per cent). Twelve patients (8 per cent) appeared to have ongoing heart inflammation.
Prof. Fontana said: “Injury relating to inflammation and scarring of the heart is common in COVID-19 patients with troponin elevation discharged from hospital, but is of limited extent and has little consequence for the heart’s function.
“These findings give us two opportunities: firstly, to find ways of preventing the injury in the first place, and from some of the patterns we have seen, blood clotting may be playing a role, for which we have potential treatments.
Secondly, detecting the consequences of injury during convalescence may identify subjects who would benefit from specific supporting drug treatments to protect heart function over time.”
The findings of the study are limited by the nature of patient selection and included only those who survived a coronavirus infection that required hospital admission.
“The convalescent patients in this study had severe COVID-19 disease and our results say nothing about what happens to people who are not hospitalised with COVID, or those who are hospitalised but without elevated troponin.
The findings indicate potential ways to identify patients at higher or lower risk and suggest potential strategies that may improve outcomes. More work is needed, and MRI scans of the heart have shown how useful it is in investigating patients with troponin elevation,” concluded Prof. Fontana. (ANI)

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Netflix’s ‘The Queen’s Gambit’ getting adapted into a stage musical

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Washington [US], March 9 (ANI): What’s in store for the award-winning Netflix series ‘The Queen’s Gambit’? A musical. The hit series may become a musical as production company Level Forward has acquired theatrical stage rights to Walter Tevis’ book ‘The Queen’s Gambit’, which served as the basis for the miniseries.
As per Variety, Tevis also wrote ‘The Hustler’ and ‘The Man Who Fell to Earth’, both of which became films and, in the case of ‘The Man Who Fell to Earth’, a stage show.
Level Forward, which produced popular shows like ‘Jagged Little Pill’ and the revival of ‘Oklahoma!’, has not announced a creative team or casting details for the upcoming project yet.
The company’s recent Broadway productions include ‘Slave Play’ and ‘Jagged Little Pill’, which currently are nominated for 12 and 15 Tony Awards, respectively.
“It is a privilege for Level Forward to lead the charge of bringing The Queen’s Gambit to the stage through the beloved and enduring craft of musical theater,” Level Forward CEO Adrienne Becker and producer Julia Dunetz said in a statement.
They added, “Told through a brave and fresh point of view, audiences are already sharing in the friendship and fortitude of the story’s inspiring women who energize and sustain Beth Harmon’s journey and ultimate triumph.”

“The story is a siren call amidst our contemporary struggles for gender and racial equity, and we’re looking forward to moving the project forward,” they further said.
The deal was brokered on Tevis Family Trust by Susan Schulman of the Susan Schulman Literary Agency, New York, and Rachel Gould on behalf of Level Forward.
The seven-episode Netflix limited series is based on Tevis’ 1983 novel of the same name, which combines the author’s real-life experiences playing chess with fictional characters.
The show, set in the 1950s and 60s, stars actor Anya Taylor-Joy as the fictional Beth Harmon, an orphan and chess prodigy who is determined to break into the male-dominated world of competitive chess. As a child, Beth was force-fed pills at her orphanage, leaving her with a drug addiction that complicates her ascent to world-class chess champion.
The series became Netflix’s most-viewed scripted limited series, garnering over 62 million viewers in its first month on the streamer. The Netflix adaptation has won two Golden Globe Awards and two Critics Choice Awards.
The novel, published in 1983, follows the journey of the fictional female chess prodigy, Beth Harmon, from Kentucky to Paris to Moscow, while she battles addiction and the prejudices of a male-centered world. At one point in the 1990s, the novel almost became a feature film, reported People magazine.
“Many directors have tried to make it. Heath Ledger was set to direct this as a film a few years before he died. This was going to be his directing debut,” series writer and director Scott Frank told Forbes, adding, “It fell through because it just wasn’t the type of movie being made at the time.”
‘The Queen’s Gambit’ had released on Netflix on 23 October 2020. (ANI)

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‘The Crown’ star Emma Corrin in talks to join ‘Lady Chatterley’s Lover’

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Washington [US], March 9 (ANI): Actor Emma Corrin, widely known for playing Diana, Princess of Wales, in Netflix’s popular period drama ‘The Crown’, is gearing up to portray another high-society woman.
As per Variety, the Golden Globe-winning actor is in talks to star in ‘Lady Chatterley’s Lover,’ an upcoming romance drama about the scandalous affair between star-crossed lovers.
Based on D.H. Lawrence’s novel, the story follows the wealthy and privileged Lady Chatterley, who finds herself married to a man she doesn’t love and engages in a torrid affair with a gamekeeper on their English estate, discovering more desire and intimacy than she thought possible. When she realizes that she has fallen heart and soul, she breaks all traditions of the day and seeks happiness with the man she loves.
The book was originally published in Italy and France in the 1920s, but it was not printed in the United States until 1959 due to obscenity.
Actor-director Laure de Clermont-Tonnerre, whose credits include ‘The Mustang’, ‘Mrs. America’ and ‘The Act’, will helm the forthcoming film. ‘Life of Pi’ fame screenwriter David Magee is on board to pen the script, and 3000 Pictures, the production company founded by Elizabeth Gabler, is backing the big-screen adaptation.
Producers include Laurence Mark, Pete Czernin and Graham Broadbent of Blueprint Pictures. Marisa Paiva and Nikki Cooper are the executives overseeing the project for 3000 Pictures.
Meanwhile, Corrin recently won the Golden Globe for actress in a television series (drama) for her portrayal of Princess Diana in the Netflix series ‘The Crown’. She will next be seen opposite singer-actor Harry Styles in the romantic drama ‘My Policeman’. Corrin also appeared in the British drama ‘Misbehaviour’ with Keira Knightley, Keeley Hawes and Gugu Mbatha-Raw. (ANI)

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Taapsee Pannu-starrer ‘Looop Lapeta’ to release on this date

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New Delhi [India], March 9 (ANI): The upcoming Bollywood film ‘Looop Lapeta’ which will bring on screen a fresh pairing is slated to hit the theatres on October 22, 2021. The comic-thriller stars Taapsee Pannu and Tahir Raj Bhasin in the lead roles.
Taapsee shared the release date of the film on her Instagram handle. She wrote, “A comic-thriller we rarely get! Brace yourself to meet Savi and Satya….. #LooopLapeta in theatres this October 22, 2021.”
The ‘Pink’ actor also shared a short clip that features the lead duo’s characters — Savi and Satya and a still from the film that perfectly showcases the on-screen romance between the two actors.

Tahir also shared the same clip on his Instagram account along with a caption that read, “Get ready for the ride of your ‘life’ with Savi and Satya…. #LooopLapeta in theatres on October 22, 2021!.”
The upcoming film is an official remake of the 1998 German movie ‘Run Lola Run’, written and directed by Tom Tykwer. Franka Potente played the titular role of Lola, while the film also starred Moritz Bleibtreu. The German film followed a woman who needs to obtain 100,000 Deutsche Mark in 20 minutes to save her boyfriend’s life.
Helmed by filmmaker Aakash Bhatia, ‘Looop Lapeta’ is being bankrolled by Sony Pictures Films India, Ellipsis Entertainment (Tanuj Garg, Atul Kasbekar), and Aayush Maheshwari.
Apart from ‘Looop Lapeta’, Taapsee has a flurry of films in her kitty including ‘Shabaash Mithu’, ‘Haseen Dillruba’, ‘Rashmi Rocket’ and ‘Dobaaraa’.
Meanwhile, Tahir, who was last seen in Nitesh Tiwari’s ‘Chhichhore,’ alongside late actor Sushant Singh Rajput and Shraddha Kapoor, is awaiting the release of ’83’, which also features Ranveer Singh and Deepika Padukone. (ANI)

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A TUMULTUOUS NIGHT BETWEEN LOVER AND THE MUSE

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Malcolm and Marie, written and directed by Sam levinson, follows the tumultuous relationship between Malcolm, a narcissistic filmmaker, and Marie, his girlfriend and muse. impressively, the film was created entirely during the pandemic, using a crew of only around 20 people and minimizing filming locations. even though the setting of the film is confined to only a luxurious apartment, Malcolm & Marie is a visual treat nonetheless. it uses windows and doors as framing devices, portraying the characters in an aesthetically pleasing way. The monochromatic hues of the film remind viewers of old hollywood glamor. The cast comprises just two members: John David washington and Zendaya, two well-known actors who are no strangers to the world of hollywood. John David washington—who has performed excellently in roles such as the protagonist in Nolan’s Tenet, and Detective Ron Stallworth in BlacKkKlansman— fails to live up to the expectations set by his previous work.

Zendaya, on the other hand, shines in her role as Marie and seems to be caught in a typecast of playing depressed characters, as depicted by her role in the television series Euphoria. Nevertheless, Zendaya is a brilliant artist and drives the plot of the film meticulously with her performance. her type-casted role works well for her in this film as she embodies Marie’s depressive and high episodes, seeming that the role was written for her from the beginning, and rightly so. Given the film only features two characters, the dialogue between them is the essence of the film and is meant to be a tool to illustrate the highs and lows of the toxic relationship between Malcolm and Marie. On paper, the dialogue is well-written, but the delivery leaves much to be desired. The monologues by the characters often come out sporadic, and many lines of dialogue fail to evoke the emotions they intend to from the viewer. The tumultuous recession and the random escalation of tension are confusing.

 The film also delves into the dilemma of being a Black artist. Malcolm’s film receives an excellent review from a “white lady” critic, but this does not appease Malcolm. The critic, a Los Angeles Times writer seems to forget that Black individuals can exist solely as individuals without blackness affecting the point of view of their art. She points out the racism the protagonist experiences despite this not being part of Malcolm’s agenda. Malcolm is infuriated by this and delivers an extended monologue criticizing her, venting his pent-up frustration of not being understood as a Black filmmaker. There are conversations surrounding racism in Malcolm’s film, and Malcolm and Marie  talks about Malcolm’s experiences as a Black filmmaker who wants to break free from the shackles of just being viewed through the lens of race. There are a lot of films exploring this theme, but  this one stands out as it delves into racial discourse from a different perspective, where characters can be viewed just as individuals like any white character would be.

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HOW PARINEETI PREPARED TO PLAY AN ACE BADMINTON PLAYER IN ‘SAINA’

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Saina Nehwal biopic was a roller-coaster ride. The film, with Parineeti Chopra in lead, has a theatrical release date and the makers are making the most of the current buzz. The film releases on 26 March.

Saina is helmed by Amol Gupte, teaser of the film was released last week leaving fans impressed with Parineeti’s look and her commendable imitation of the Olympic winning badminton player.

The team also got public display of support from Saina herself as she shared the teaser on social media and wrote, “Always makes me proud to see my national flag soar high!” Saina also complimented Parineeti’s look, writing, “Woww this is superb… love the look as mini saina.”

The teaser gives us glimpses into the badminton champ’s life and how she took up the sport early on, when she was a small girl, and how India cheered for her as she participated in international tournaments. 

Parineeti also spoke about the contribution of women in her family in her journey. “I have been brought up in a family where there was not any disparity between men and women. I came across to gender disparity after I entered Bollywood. My parents spent the most on my education and there were several times when I was given more opportunities than my brothers. So, I don’t even know why we talk about it.”

The actor spoke on the real strength of the biopic, saying, “The winning point for the film is how it shows what went into making Saina a winner. It was about Saina’s complete journey.”

Shraddha Kapoor was a going to play Saina, she had trained herself for the role and shot some scenes for the film but she was diagnosed with dengue and later Parineeti was finalised to play the lead role.

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APARSHAKTI OPENS UP ABOUT WORKING WITH FEMALE DIRECTORS

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New Delhi: On the occasion of international women’s Day, Aparshakti Khurana spoke about his favourite female directors and the positive energy they bring with their craft. Three years back, leena Yadav directed Aparshakti in Rajma Chawal, a slice-of-life film. The actor captured the attention of the viewers with his earnest performance which was sketched and molded by the director. in 2019, Aparshakti appeared in Ruka Ruka, a music single with singer Shalmali. The music video was directed by Ukrainian director Dar Gai. A while back, Aparshakti shot for an anthology film and one of the directors on that project is Nitya Mehra of Made In Heaven and Baar Baar Dekho fame. Two years back, Aparshakti was directed by director-writer, Tahira Kashyap. “i have had the good fortune of working with these women directors,” he said.

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