STUDY ASSERTS BLOOD ENZYME ACTIVITY LEVEL MAY INDICATE WHICH BREAST CANCERS ARE GROWING SLOW - The Daily Guardian
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STUDY ASSERTS BLOOD ENZYME ACTIVITY LEVEL MAY INDICATE WHICH BREAST CANCERS ARE GROWING SLOW

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Patients with metastatic hormone receptor-positive breast cancer who have low activity levels of the enzyme sTK1 in their blood serum at the start of anti-estrogen treatment live longer and go longer without their disease progressing than patients with high levels, according to a recent study by SWOG (the Southwest Oncology Group) Cancer Research Network.

The findings of the study were published in the journal ‘Clinical Cancer Research’. The results suggest that patients with low sTK1 activity levels have a slow-growing disease that can be controlled initially with single-drug endocrine therapy for a prolonged period.

It remains to be determined whether these patients gain further benefit from adding a CDK4/6 inhibitor to their endocrine therapy. The findings come from an analysis of serum samples from 432 women with breast cancer who took part in the S0226 clinical trial, which was conducted by the SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH).

“SWOG researchers have demonstrated that a blood serum test can identify which of these patients have a slow-growing disease that might be controlled with a simple aromatase inhibitor pill alone,” said Dr Lajos Pusztai, MD, DPhil, professor of medicine (medical oncology) at Yale Cancer Center, who is a co-author on the paper.

Study S0226 found that most women with metastatic hormone-receptor-positive breast cancer who have not had previous treatment for their metastatic breast cancer live longer when they get a combination of the endocrine therapy drugs anastrozole and fulvestrant than when they get just anastrozole.

However, not all patients see extra benefit from the combination; some do just as well on a single drug. Having a way to identify which patients would not derive added benefit from the combination could save these patients the additional side effects and extra costs associated with taking two drugs instead of one.

The work was led by Costanza Paoletti, MD, who was then with the University of Michigan Rogel Cancer Center. She and her colleagues measured the level of serum thymidine kinase 1, or sTK1, considered a marker of cellular proliferation, in 1,726 samples taken from S0226 patients before the start of their treatment and at four-time points during treatment.

The samples were evaluated using a commercially available test known as the DiviTum assay, produced by Biovica International of Uppsala, Sweden, which measures levels of the enzymatic activity of sTK1. The researchers found what was considered high levels of the enzyme in samples from 171, or 40 per cent, of the patients.

Patients with high sTK1 levels, either before treatment or at any time during treatment, tended to have a significantly shorter period of time before their disease advanced (progression-free survival time, or PFS). Those with high levels at the start of treatment, or baseline, had a median PFS of only 11.2 months compared to 17.3 months for patients with low levels at baseline.

The high-sTK1 patients also died sooner, on average, than patients with low levels of the biomarker, with median overall survival times of just 30 months versus 58 months.

Importantly, patients with low sTK1 levels did just as well on the single drug anastrozole as on the combination. This means a measurement of pretreatment sTK1 level could potentially be used to determine whether a patient should start treatment with two-drug endocrine therapy (high sTK1) or single-drug endocrine therapy (low sTK1).

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PGIMER releases documentary titled ‘Front of Package Labeling: A Game Changer for Healthy India’

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A documentary titled ‘Front of Package Labeling: A Game Changer for Healthy India’, prepared by the Department of Community Medicine and School of Public Health (DCM & SPH), Post Graduate Institute of Medical Education and Research, Chandigarh.

This documentary is a part of a project being undertaken by the Institute in collaboration with Government of Punjab and Strategic Institute of Public Health Education and Research (SIPHER) and is supported by Global Health Advocacy Incubator, USA.

“A rapid rise in hypertensive cases is being observed in Punjab, which is worrisome. Through the project, we are collaborating with the Government of Punjab to prevent and better manage hypertension through sensitization of media and the general public regarding the risk factors like trans fats in food. We strongly feel that warning labels on food items are effective way of helping people to make nutritious food choices. The documentary drives home the importance of Front of Package Labeling (FOPL) for averting a cardiovascular health, obesity and diabetes crisis in India.” said Dr. Sonu Goel.

As per WHO, Non-communicable diseases (NCDs’) account for 70% of the global deaths. The state of Punjab has become a capital of hypertension with one out of three people suffering from this silent killer.

Excessive intake of fats, sugar and salt available in packaged foods such as cake, pizza, pastry, french fries, ice cream, etc. are the primary cause of NCDs. Under this project which started in 2019, PGIMER Chandigarh has signed a pact with Food and Drug Administration, Punjab to implement and regulate the trans-fat surveillance in Punjab.

The documentary highlights key features such as transition of food practices from traditional to modern, ways to making healthy food choices, identifying good and bad food, diseases associated with bad food. etc.

It was released at the juncture of festivals such as Diwali, aims to generate awareness among policymakers, implementers, and the general public about the importance of healthy and wholesome food to keep Non-Communicable Diseases (NCDs’) like hypertension at bay and to generate support for an intense Front-of-Pack Labelling (FOPL) policy to be developed by Government of India. It took around two months to prepare this documentary of approximately 7 minutes, which is a collaborative effort of the project team. The documentary has been conceptualized and narrated by Dr. Sonu Goel, Professor, Dept. of Community Medicine and School of Public Health, PGIMER, Chandigarh and Principal Investigator of the project.

Dr. Geeta Mehra, Head, Dept. of Food Sciences, MCM DAV College, Chandigarh emphasized the importance of reading food labels while purchasing any packaged food product. She stressed that “FOPL, if implemented in India, will allow the consumers to identify products containing excess sugars, trans-fats, oils, and sodium easily, quickly, and correctly and help them to make informed food choices.”

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STUDY SHOWS REGULAR MILLET CONSUMPTION CAN COMBAT ANAEMIA

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A new study has shown that regular consumption of millets can improve haemoglobin and serum ferritin levels to reduce iron deficiency anaemia, which is rising globally.

The findings of the study were published in the journal ‘Frontiers in Nutrition’. The research, a meta-analysis of 22 studies on humans and eight laboratory studies on millets consumption and anaemia, was undertaken by seven organisations across four countries and was led by the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT).

“The study concluded that millets can provide all or most of the daily dietary iron requirements of an average person. Although the amount of iron provided depends on the millet variety and its form of processing, the research clearly shows that millets can play a promising role in preventing and reducing high levels of iron deficiency anaemia,” highlighted Dr S Anitha, the study’s lead author and Senior Nutritionist at ICRISAT.

The researchers found that millets increased haemoglobin levels by as much as 13.2 per cent. Four studies in the review also showed serum ferritin increasing by an average of 54.7 per cent. Ferritin is an iron-containing protein in the blood and is a clinical marker for iron deficiency.

The studies in the analysis involved nearly 1,000 children, adolescents and adults, and six different millet types – finger millet, pearl millet, sorghum and a mixture of kodo, foxtail and little millets. The participants in the studies were found to have consumed millets for anywhere between 21 days and 4.5 years. The findings were published on 14 October in Frontiers in Nutrition.

“1.74 billion people were anaemic in 2019. That number is rising,” said Dr Jacqueline Hughes, Director General, ICRISAT.

“It has been proven that iron deficiency anaemia affects cognitive and physical development in children and reduces productivity in adults. The need for a solution is critical, and therefore bringing millets into mainstream and government programs is highly recommended,” added Dr Hughes.

“Now that there is strong evidence of the value of millets in reducing or preventing iron deficiency anaemia, it is recommended that one major research study be undertaken on anaemia covering all the different types of millet, common varieties and all major forms of processing and cooking, using a uniform testing methodology. This will provide the detail required for designing interventions needed to have a major impact on reducing anaemia globally,” said Professor Ian Givens, a co-author of the study and Director at the University of Reading’s Institute of Food, Nutrition and Health (IFNH) in the UK.

“It has often been claimed that iron in millets is not highly bioavailable due to the supposed high levels of antinutrients. Our analysis proves this is a myth. Instead, millets were found to be comparable to typical iron bioavailability percentages for plants. Also, the levels of antinutrients in millets were identified to be similar or lower than common staples,” said Ms Joanna Kane-Potaka, former Assistant Director-General, ICRISAT, and Executive Director of the Smart Food initiative who is a co-author of the study.

The research also showed that processing can significantly increase the amount of iron bioavailable. For example, millet snacks made by expansion (extrusion) increased bioavailable iron 5.4 times, while fermentation, popping and malting more than tripled the iron bioavailable. Germination (sprouting) and decortication (dehulling) more than doubled the bioavailable iron.

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Benefits of eating nuts for breast cancer survivors

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Can eating nuts have health-protective effects for breast cancer survivors? A new study suggests that it might!

According to the study, nut consumption is associated with lower risks of breast cancer recurrence or death. The findings of the study were published in the ‘International Journal of Cancer’.

Among 3,449 breast cancer survivors from the Shanghai Breast Cancer Survival Study, who completed a dietary assessment 5 years after diagnosis, there were 374 deaths during a median follow-up of 8.27 years after the dietary assessment.

Among 3,274 survivors without a previous recurrence at the time of their dietary assessment, 209 developed breast cancer-specific events, including recurrence, metastasis, or breast cancer mortality.

There was a dose-response pattern in the relationship between nut consumption and risk of breast cancer recurrence or death, with those consuming the highest amounts having the lowest risks.

Also, the association was stronger for survivors who had earlier stages of breast cancer than for those who had later stages.

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Study finds orange juice helps fight inflammation, oxidative stress

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A new study has suggested 100 per cent orange juice has the potential to help fight inflammation and oxidative stress in adults.

The findings of the study were published in the journal ‘Advances in Nutrition’.

Though limited in scope, the study indicates drinking 100 per cent orange juice significantly reduces interleukin 6, a well-established marker of inflammation, in both healthy and high-risk adults. Two additional inflammatory and oxidative stress markers were also reduced; however, the results did not quite reach statistical significance.

The findings of this study, which was funded through an unrestricted grant by the Florida Department of Citrus, harmonise with a previously published FDOC-funded review that reported beneficial effects of hesperidin, the primary bioactive compound found in oranges and 100 per cent orange juice, on reducing some markers of inflammation and oxidative stress. Chronic inflammation may play a key role in causing or advancing some chronic diseases, including heart disease and diabetes.

“We know that 100 per cent orange juice contains a number of nutrients, like vitamin C, as well as beneficial bioactive compounds that have the potential to reduce inflammation and oxidative stress,” said Gail Rampersaud, Florida Department of Citrus registered dietitian.

“This review tells us that some studies find benefits with 100 per cent orange juice, but we need more data and large well-designed studies to make more definitive conclusions. This analysis is especially helpful as we and others plan future research related to orange juice,” added Rampersaud.

The review examined published studies relating to 100 per cent orange juice and markers of inflammation and oxidative stress. The review was conducted by the Think Healthy Group and researchers at Tufts University and George Mason University.

The analysis consisted of three parts: a qualitative scoping review of 21 studies with a total of 307 healthy adults and 327 adults at risk for disease; a systematic review of a subset of 16 studies that measured the six most reported biomarkers related to inflammation and oxidative stress in the body; and 10 studies that had sufficient data to conduct a meta-analysis. The researchers also examined the overall quality and potential bias in the studies.

The broad scoping and systematic reviews revealed that, in general, 100 per cent orange juice either had beneficial or null (no adverse) effects on oxidative stress or inflammation. The researchers cautioned that studies included a relatively small number of subjects, had a low strength of evidence, and had a moderate risk of bias; therefore, overall findings should be interpreted with caution.

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WHAT IS THE BONE DENSITY TEST? WHEN SHOULD ONE DO IT?

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Data suggests that 20% of women over the age of 50yrs are highly susceptible to Osteoporosis in India alone. Globally approximately 200 million people are estimated to be affected by the disease. Now you might wonder, what is this condition affecting millions worldwide and, more so, women significantly?

Osteoporosis, simply put, translates to porous and weak bones. This state also means the individual has less bone mass, thus making them more prone to frequent fractures. A person’s risk of the disease increases with age, i.e., 50 in most cases. In the case of women, menopause is a primary risk factor. Some other lifestyle choices which put you at the peril of Osteoporosis include smoking, excessive and frequent alcohol intake, sedentary lifestyle, no Calcium, Vitamin D and other necessary minerals, nutrients in your diet, protein deficient diet.

One can’t usually figure out whether they have Osteoporosis; it is only evident after high-impact painful fractures and through diagnostic tests. So which test must one undergo to understand whether they have Osteoporosis? The answer is Bone Density Test. Here, X-rays are utilised to measure the strength of bone and its fragility. Usually, the forearm, hip, thigh (femur) and spine are examined in a Bone Density Test (BDT). These are the most vulnerable areas for Osteoporosis.

Types of Bone Density Test: The most common and accepted test to diagnose Osteoporosis is the Central DXA (Dual-energy X-ray Absorptiometry), where pictures of the lumbar spine and hips are produced to determine bone loss. It can be used for other parts of the body as well. There is Quantitative Computed Tomography too, but it is less practised as it has higher amounts of radiation and is expensive.

Alternatives to DXA include: Peripheral Dual-energy X-ray Absorptiometry (pDXA) for the wrist and heel; Quantitative Ultrasound (QUS) to measure the bone density in the heels; Peripheral Quantitative Computed Tomography (pQCT) for the wrist.

WHY IS THE BONE DENSITY TEST DONE?

Diagnosing Osteoporosis

The test checks if the treatment of Osteoporosis is helping or improving the condition. The scan further helps to conclude whether the individual is going to develop fractures in the future.

WHEN SHOULD ONE GET CHECKED?

If you are past the age of 50yrs; the age group of 50-65yrs is a vulnerable one. You should get checked if your body structure is petite and thin, as low weight individuals are at a greater risk of Osteoporosis; If you are a postmenopausal woman; should you have Rheumatoid Arthritis; it is best to get a Bone Density Test done; family history of Osteoporosis, hip fracture, and smoking; have hyperthyroidism and have consumed Corticosteroid drugs for more than three months.

The DXA test is non-invasive and doesn’t cause any pain. However, repeated exposure to radiation is not recommended. Thus lead a healthy lifestyle, take adequate protein, calcium and vitamin D, do regular impact loading exercises and keep your bones strong.

The writer is a Director-Orthopedics & Joint Replacement Surgery, Fortis Hospital, Mulund

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Illness related messages significant motivators for exercise

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Fitness apps that emphasize illness- or death-related messaging are more likely to be effective in motivating participation than are social stigma, obesity, or financial cost messaging, according to a recent study led by researchers at the University of Waterloo.

The study, ‘The Relationship between Perceived Health Message Motivation and Social Cognitive Beliefs in Persuasive Health Communication’, was published in the journal MDPI (Multidisciplinary Digital Publishing Institute) and was authored by Oyibo, with Julita Vassileva, a Persuasive System Design professor at the University of Saskatchewan, assisting with the data collection.

Previous studies, especially on smoking cessation and risky sexual behaviour, found that messages related to mortality could be a barrier to acknowledging health risks, but the study found this is the opposite for fitness apps.

The study asked 669 research participants to indicate how persuasive these five types of messages were in terms of motivating them to work out at home with a fitness app, to uncover their effectiveness, connection with social-cognitive beliefs such as self-regulation (goal setting), self-efficacy, and outcome expectation, and seeing what role male/female gender played.

“I did not expect only illness- and death-related messages to be significant and motivational,” said Kiemute Oyibo, a postdoctoral fellow at the University of Waterloo’s School of Public Health Sciences.

Oyibo added, “Not only were illness- and death-related messages motivational, they had a significant relationship with self-regulatory belief and outcome expectation, and there was no significant difference between males and females.”

Oyibo said he had expected obesity-related messages (such as “one in four Canadians has clinical obesity”) to be motivational and have a significant relationship with self-regulatory belief, given that obesity is associated with the leading causes of global mortality.

“This study is important because it helps us – especially designers of health apps – understand the types of messages that individuals, regardless of gender, are likely to be motivated by in persuasive health communication, and that are likely to influence individuals’ social-cognitive beliefs about exercise,” Oyibo said.

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