Sodium-glucose transporter-2 (SGLT2) inhibitors, which reduce renal glucose reabsorption, may help control blood sugar and protect kidney health in patients with diabetic renal failure; however, several large clinical trials have linked these drugs to a higher risk of bone fracture.
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In a recent study published in the journal CJASN, an SGLT2 inhibitor was not associated with a higher risk of fracture than another diabetes drug, regardless of the patient’s kidney function. The study, which was conducted by Andrea Cowan, MD (London Health Sciences Centre) and her colleagues, compared fracture rates in adults aged 66 years or older who were prescribed SGLT-2 inhibitors vs. those prescribed a different diabetes medication–called dipeptidyl peptidase (DPP-4) inhibitors that have not been linked to fractures. .”
Sodium glucose transport 2 inhibitors do not appear to increase fracture risk, even in older adults with moderate kidney dysfunction.