Jim Parsons was initially turned down after his audition for 'The Big Bang Theory' - The Daily Guardian
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Jim Parsons was initially turned down after his audition for ‘The Big Bang Theory’

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Washington [US], February 11 (ANI): Creators of the American television sitcom ‘The Big Bang Theory’ recently revealed that actor Jim Parsons, who played the iconic role of Sheldon Cooper on the CBS show was almost turned down initially.
According to People magazine, Bill Prady, who created the show alongside Chuck Lorre revealed during an appearance on the ‘At Home with the Creative Coalition’ podcast that Lorre wasn’t initially sure about casting Parsons following his audition.
Prady recalled of the audition process and said “when Jim Parsons came in, he was Sheldon on a level — you know, there were people who came in and you went, ‘Okay, well, he’s kind of okay,’ ‘Oh, he’s pretty good,’ ‘Maybe he’s the guy.’ And Jim came in and he was just — from that audition, he was the Sheldon that you saw on television.”
He further added that “He created that character at that audition, and he left the room and I turned and I went, ‘That’s the guy! That’s the guy! That’s the guy!’ And Chuck turned and he said, ‘Nah, he’s gonna break your heart. He’ll never give you that performance again.'”
Prady stated that this disagreement was the only time Lorre’s instinct was wrong and he was right.
The rest was history, with Parsons helping to make Sheldon one of the most popular characters in comedy history. It even inspired the ‘Young Sheldon’ spin-off series based on the character’s life as a child.
Parsons starred as Sheldon on ‘The Big Bang Theory’ from its premiere in 2007 until its series finale in 2019. (ANI)

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Crowd of fans hinder Varun Dhawan’s ‘Bhediya’ shoot in Arunachal Pradesh

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Itanagar (Arunachal Pradesh) [India], March 8 (ANI): The eagerness of fans to catch a glimpse of the stars interrupted the shooting of the Varun Dhawan and Kriti Sanon starring horror-comedy film ‘Bhediya’ on Sunday night.
The shoot of Varun Dhawan’s upcoming horror-comedy flick ‘Bhediya’ was interrupted by his fans at Sagalee Ground in Arunachal Pradesh as they got excited to catch a glimpse of him.
In a video, going viral on the internet, the ‘Badlapur’ actor is seen climbing n top of a car while requesting the crowd to let them resume the shoot.
Varun is heard appealing to fans to maintain peace.
He said, “Thode time ke liye humlog hai idhar. Bohot time ke liye hai. Toh hopefully, shooting jab khatam hota hai toh main aap sab se mil paunga (We will be here for quite some time. Hopefully, once the shooting ends, I will be able to meet you all).”
A few days after disclosing details of their horror-comedy project together, Varun and Kriti had landed in Arunachal Pradesh to shoot for the first schedule of their film ‘Bhediya’.
Before getting their film on floors, the entire team met Pema Khandu, honourable Chief Minister of the state. Minister of home and interstate affairs Bamang Felix, Chief secretary Naresh Kumar, Commissioner to HCM- Sonam Chombey were also present during the meeting.

The horror-comedy drama ‘Bhediya’ will mark the ‘Badlapur’ star and ‘Heropanti’ star’s third collaboration with each other after sharing screen spaces in 2015 rom-com ‘Dilwale’ and 2019 ‘Kalank’.
‘Bhediya’ will bring together the dynamic duo of producer Dinesh Vijan and director Amar Kaushik, who also helmed the 2018 blockbuster movie ‘Stree’. Starring Kriti Sanon, Varun Dhawan, Abhishek Banerjee, and Deepak Dobriyal, the story is written by National Award Winner, Niren Bhatt who also wrote intriguing scripts for ‘Bala’, ‘Made In China’, ‘Wrong Side Raju’.
The film is slated to release in cinemas on April 14, 2022. (ANI)

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Amazon Prime Video announces original series ‘Hush Hush’, an all-female led series

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Mumbai (Maharashtra) [India], March 8 (ANI): On the occasion of International Women’s Day, Amazon Prime Video is all set to announce its upcoming series ‘Hush Hush’ (working title), led by an all-women cast and crew.
Not only is Amazon Original ‘Hush Hush’ (working title) a story with strong female protagonists, but it is also helmed by some of the finest female talent behind the camera.
Filmmaker Tanuja Chandra (‘Qarib Qarib Singlle’, ‘Dushman’, ‘Sangharsh’ fame) will serve as the Creative Director and Executive Producer, and Shikhaa Sharma screenwriter of ‘Shakuntala Devi’, ‘Toilet – Ek Prem Katha’, ‘Sherni’ will double as Executive Producer and original story writer.
Kopal Nathani, one of the most promising names in the advertising films industry will direct episodes in the show. National Award-winning writer Juhi Chaturvedi (‘Gulabo Sitabo’ and ‘Piku’) has been roped in to pen the dialogues for the series written by Ashish Mehta.
The series will be produced by Vikram Malhotra’s Abundantia Entertainment which is the production house behind ‘Breathe, Breathe: Into the Shadows’, ‘Shakuntala Devi’, and ‘Airlift’.
‘Hush Hush’ (working title) marks the digital debut of award-winning Indian movie star Juhi Chawla as well as that of Ayesha Jhulka with leading ladies Soha Ali Khan, Karishma Tanna, Shahana Goswami and Kritika Kamra will also be playing pivotal roles in this thriller-drama.
With a unique female gaze at its core, ‘Hush Hush’ propels forward the movement of women telling their own stories. The drama features an almost all-female crew, right from the Production Designer, Costume Designer, Surpervising Producer, Co-producers, to Art, Costume, Production Coordination to even the Security Team!
Speaking on the greenlight announcement Tanuja Chandra, creative director and executive producer of ‘Hush Hush’ (working title), said, “Video streaming in India has brought about a significant change in storytelling by pushing female narratives to the fore and I couldn’t be more pleased! It’s what directors like me have waited for.”
“Amazon Prime Video and Abundantia Entertainment, both have been bringing diverse and authentic women’s stories to audiences in India and abroad for a while now and I’m thrilled to join forces with them for Hush Hush to create something with this wonderful team that I hope will be truly special,” she added.
Prime members in India and across 240 countries and territories will be able to stream ‘Hush Hush’ (working title) exclusively on Amazon Prime Video.
The release date has still been kept under wraps. (ANI)

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Night shift work may increase cancer risk, says study

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Washington [US], March 8 (ANI): A new study conducted by researchers at Washington State University has found new clues as to why night shift workers may be at increased risk of developing certain types of cancer compared to those who work regular daytime hours.
Findings suggest that night shifts disrupt natural 24-hour rhythms in the activity of certain cancer-related genes, making night shift workers more vulnerable to DNA damage while also causing the body’s DNA repair mechanisms to be mistimed to deal with that damage.
Published online in the Journal of Pineal Research, the study involved a controlled laboratory experiment that used healthy volunteers who were on simulated night shift or day shift schedules.
Though more research still needs to be done, these discoveries could someday be used to help prevent and treat cancer in night shift workers.
“There has been mounting evidence that cancer is more prevalent in night shift workers, which led the World Health Organization’s International Agency for Research on Cancer to classify night shift work as a probable carcinogenic,” said co-corresponding author Shobhan Gaddameedhi, an associate professor formerly with the WSU College of Pharmacy and Pharmaceutical Sciences and now with North Carolina State University’s Biological Sciences Department and Center for Human Health and the Environment.
“However, it has been unclear why night shift work elevates cancer risk, which our study sought to address.”
As part of a partnership between the WSU Sleep and Performance Research Center and the U.S. Department of Energy’s Pacific Northwest National Laboratory (PNNL), Gaddameedhi and other WSU scientists worked with bioinformatics experts at PNNL to study the potential involvement of the biological clock, the body’s built-in mechanism that keeps us on a 24-hour night and day cycle.
Though there is a central biological clock in the brain, nearly every cell in the body also has its own built-in clock. This cellular clock involves genes known as clock genes that are rhythmic in their expression, meaning their activity levels vary with the time of day or night. The researchers hypothesized that the expression of genes associated with cancer might be rhythmic, too, and that night shift work might disrupt the rhythmicity of these genes.
To test this, they conducted a simulated shift work experiment that had 14 participants spend seven days inside the sleep laboratory at WSU Health Sciences Spokane. Half of them completed a three-day simulated night shift schedule, while the other half were on a three-day simulated day shift schedule.
After completing their simulated shifts, all participants were kept in a constant routine protocol that is used to study humans’ internally generated biological rhythms independent of any external influences.
As part of the protocol, they were kept awake for 24 hours in a semi-reclined posture under constant light exposure and room temperature and were given identical snacks every hour. Every three hours a blood sample was drawn.
Analyses of white blood cells taken from the blood samples showed that the rhythms of many of the cancer-related genes were different in the night shift condition compared to the day shift condition. Notably, genes related to DNA repair that showed distinct rhythms in the day shift condition lost their rhythmicity in the night shift condition.
The researchers then looked at what the consequences of the changes in the expression of cancer-related genes might be. They found that white blood cells isolated from the blood of night shift participants showed more evidence of DNA damage than those of day shift participants.
What’s more, after the researchers exposed isolated white blood cells to ionizing radiation at two different times of day, cells that were radiated in the evening showed increased DNA damage in the night shift condition as compared to the day shift condition.
This meant that white blood cells from night shift participants were more vulnerable to external damage from radiation, a known risk factor for DNA damage and cancer.
“Taken together, these findings suggest that night shift schedules throw off the timing of expression of cancer-related genes in a way that reduces the effectiveness of the body’s DNA repair processes when they are most needed,” said co-corresponding author Jason McDermott, a computational scientist with the Pacific Northwest National Laboratory’s Biological Sciences Division.
The researchers’ next step is to conduct the same experiment with real-world shift workers who have been consistently on day or night shifts for many years to determine whether in night workers the unrepaired DNA damage builds up over time, which could ultimately increase the risk of cancer.
If what happens in real-world shift workers is consistent with the current findings, this work could eventually be used to develop prevention strategies and drugs that could address the mistiming of DNA repair processes.
It could also be the basis for strategies to optimize the timing of cancer therapy so that treatment is administered when effectiveness is greatest and side effects are minimal, a procedure called chronotherapy that would need to be fine-tuned to the internal rhythms of night workers.
“Nightshift workers face considerable health disparities, ranging from increased risks of metabolic and cardiovascular disease to mental health disorders and cancer,” said co-senior author Hans Van Dongen, a professor in the WSU Elson S. Floyd College of Medicine and director of the WSU Sleep and Performance Research Center.
“It is high time that we find diagnosis and treatment solutions for this underserved group of essential workers so that the medical community can address their unique health challenges.” (ANI)

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‘Sandeep Aur Pinky Faraar’: New trailer to unveil fresh insights into crazy adventures of characters

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Mumbai (Maharashtra) [India], March 8 (ANI): Known for pushing quirky content in Indian cinema, filmmaker Dibakar Banerjee is all set to release a new trailer of his upcoming movie ‘Sandeep Aur Pinky Faraar’ (SAPF) tomorrow that will unveil more insights into the crime thriller.
The nail-biting thriller features the ‘Ishaqzaade’ duo of Arjun Kapoor and Parineeti Chopra in the lead. While Kapoor plays an undercover cop in the film, Chopra will be essaying the role of a corporate employee who is absconding.
The first trailer of the flick was released in March, last year. Now, with a new trailer release tomorrow the director of the film is gearing up to tease the audience with more glimpses into the raw and real-world of the crime thriller.
Dibakar said, “SAPF has taken so long to come to the screen that it has become my other Khosla. Audiences and filmmakers all over the world have had an eventful past year. It’s only when something is taken away from us do we realise the true value of it.”
He added that he wanted ‘SAPF’ to be a film that couples, families, gangs of friends would watch in the theatres and then go out for dinner to argue about it.
“Now, that we will be one of the first films to open theatrically I’m waiting to watch if that happens (with masks on!) or the audience passes the genre-bending and independent-minded to go for the summer blockbusters that are waiting for us to be the cannon fodder and then come in and wave their victory flags!,” he continued.
‘Sandeep Aur Pinky Faraar’ was supposed to release last year. Due to the COVID-19 induced pandemic, Dibakar is hoping that the film will entertain audiences as they return to normalcy after living a year in isolation.
He said, “We are the only film in history perhaps to run a trailer for a year before the release! But there’s a second trailer for those who want fresh insights into the crazy adventures of Sandy and Pinky”.
“And I still want couples, families and friends fighting about who’s film it was – Sandy aur Pinky – with masks on – at a theatre next door. I want all of us to be safe, be entertained and reclaim a bit of our lost lives – like Sandy and Pinky in the film,” he added.
The upcoming film will see Arjun play the role of a Haryanvi cop quirkily named Pinky, while Parineeti will essay the role of an ambitious girl from the corporate world named Sandeep, whose lives suddenly intertwine.
Dibakar is presenting Arjun Kapoor and Parineeti Chopra in an all-new avatar and today revealed a massive secret that Arjun’s character is called Pinky and Parineeti’s Sandeep! Audiences have so far definitely thought otherwise and this reveal sets the tone for the trailer and the film which will see numerous and totally unexpected edge-of-the-seat twists.
Produced by Dibakar Banerjee Productions, Sandeep Aur Pinky Faraar will be released worldwide by Yash Raj Films. (ANI)

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Life as a member of the royal family affected mental health: Meghan Markle tells Oprah

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Washington [US], March 8 (ANI): In an interview with American talk show host Oprah Winfrey, Duchess of Sussex Meghan Markle said that her life as a member of the royal family had affected her mental health and she had thoughts of self-harm but her senior aides declined to help.
According to People Magazine, the 39-year-old disclosed that she had thoughts of self-harm while being a part of the royal family.
During her interview with Oprah Winfrey, Meghan Markle said, “I was ashamed to say it at the time and ashamed to have to admit it to Harry. But I knew that if I didn’t say it then I would do it,” she said.
She continued, “I just didn’t want to be alive anymore! That was clear and real and frightening and constant thought.”
She also reminisced about how her husband Prince Harry cradled her and they went to the institution to seek help, but the senior aides refused to do so.
“I told them that I have never felt this way before, and I need to go somewhere. I was told that I couldn’t, that it wouldn’t be good for the institution,” she told.
Meghan also recalled a January 2019 outing to see a performance at Royal Albert Hall after she had opened up to Prince Harry about her thoughts. “I remember him saying, ‘I don’t think you can go,’ and I said, ‘I can’t be left alone,’ ” she added.
People Magazine also reported that the Duchess of Sussex also revealed that every time the theater’s lights went down, she was “weeping”.
“And that’s I think so important for people to remember is you have no idea what’s going on for someone behind closed doors. Even the people that smile and shine the brightest lights, you need to have compassion for what it actually potentially going on,” she said.
The interview also revealed that the soon-to-be-mom was “ashamed” of admitting her situation to Harry because, “because I wanted to be strong and not put more pressure on him”.
“It takes so much courage to admit that you need help,” she told. (ANI)

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‘Rani Mukerji inspired me to become an actor’, says ‘Bunty Aur Babli 2’ star Sharvari

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Mumbai (Maharashtra) [India], March 8 (ANI): To mark International Women’s day, Bollywood debutant Sharvari, who will be seen opposite Siddhant Chaturvedi in ‘Bunty Aur Babli 2’, has posted a heartfelt wish for her screen idol Rani Mukerji on Monday.
Sharvari credited Rani for giving audiences, including her, some of the most memorable women role models through Rani’s choice of characters.
The 24-year-old took to her Instagram story and posted a picture with the ‘Mardaani’ star. Alongside the picture, she wrote, “I have idolised a lot of women characters who I have seen on the big screen and invariably most of those women have been played by none other than Rani ma’am! So, on women’s day this is my appreciation post for her. Thank you for inspiring me to be an actor.”

“It was such a dream come true for me! Happy women’s day to all the babli’s out there!,” she concluded.
Sharvari’s debut is touted to be one of the biggest launches in Bollywood this year. ‘Bunty Aur Babli 2’, produced by Yash Raj Films, is set to release on April 23. Sharvari and Rani will share the screen together in the film as well.
The film, in an exciting casting coup, also reunites Saif Ali Khan and Rani Mukerji and will present them as the original ‘Bunty Aur Babli’ in the film. (ANI)

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